Combined chemotherapy and I-125-particle implantation for treatment of children with head and neck soft tissue sarcomas improve the short-term efficacy: Beijing Children's Hospital experience over 2 years
Objective: To evaluate the efficacy of chemotherapy combined with I-125 seed implantation in treating pediatric head and neck soft tissue sarcomas. Methods: The clinical characteristics, overall survival rate, local control rate and event free survival rate of patients treated with chemotherapy and 125I seed implantation were studied retrospectively. Results: There were 12 males and 2 female patients. Age at diagnosis ranged between 1.0-10.7 years, and the median age is 4.9 years. Only 3 of the patients had localized disease, the other 11 patients had metastatic disease. The follow up time ranged from 8 to 30.5 months, median follow up time was 12.3 months. The overall response rate (complete response, very good patial response and partial response; CR, VGPR and PR) for all 14 patients was 85%, including 6/14 patients with CR, 1/14 patient with VGPR, 5/14 patients with PR. 2/14 patients had progressive disease. The overall local control rate was 85%, with a median LC time 18.9 months (95% CI: 16.4 to 21.3 month). The overall survival rate in this group of patients was 100%. The overall survival time was 8 to 30.5 months. The event free survival rate was 85%, with a median EFS time 18.9 months (95% CI: 16.4 to 21.3 months). Hematological toxicity was the most common side effects of chemotherapy. 7 of 14 patients suffered from grade 1 or 2 skin reaction after seed implantation. Conclusions: Chemotherapy combined with I-125 seed implantation is a feasible treatment for children with head and neck sarcomas, with high local control rates and event free survival.
基金：
Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support [ZY201404]; Beijing Municipal Science and Technology Commission of the Capital Special Funding Support [Z151100004015159]
第一作者机构：[1]Capital Med Univ, Beijing Childrens Hosp, Beijing Key Lab Pediat Hematol Oncol, 56 Nanlishi Rd, Beijing, Peoples R China;[2]Capital Med Univ, Beijing Childrens Hosp, Natl Key Discipline Pediat, Minist Educ, 56 Nanlishi Rd, Beijing, Peoples R China;[3]Capital Med Univ, Beijing Childrens Hosp, Hematol Oncol Ctr, 56 Nanlishi Rd, Beijing, Peoples R China;
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Childrens Hosp, Beijing Key Lab Pediat Hematol Oncol, 56 Nanlishi Rd, Beijing, Peoples R China;[2]Capital Med Univ, Beijing Childrens Hosp, Natl Key Discipline Pediat, Minist Educ, 56 Nanlishi Rd, Beijing, Peoples R China;[3]Capital Med Univ, Beijing Childrens Hosp, Hematol Oncol Ctr, 56 Nanlishi Rd, Beijing, Peoples R China;[5]Capital Med Univ, Hematol Oncol Ctr, Beijing Childrens Hosp, Nan Li Shi Rd, Beijing 100045, Peoples R China
推荐引用方式(GB/T 7714)：
Duan Chao,Zheng Lei,Jin Mei,et al.Combined chemotherapy and I-125-particle implantation for treatment of children with head and neck soft tissue sarcomas improve the short-term efficacy: Beijing Children's Hospital experience over 2 years[J].INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE.2016,9(6):11901-11906.
APA：
Duan, Chao,Zheng, Lei,Jin, Mei,Zhang, Dawei,Zhao, Wen...&Zheng, Huyong.(2016).Combined chemotherapy and I-125-particle implantation for treatment of children with head and neck soft tissue sarcomas improve the short-term efficacy: Beijing Children's Hospital experience over 2 years.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,9,(6)
MLA：
Duan, Chao,et al."Combined chemotherapy and I-125-particle implantation for treatment of children with head and neck soft tissue sarcomas improve the short-term efficacy: Beijing Children's Hospital experience over 2 years".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 9..6(2016):11901-11906
