机构:[1]Capital Med Univ, Beijing Neurosurg Inst, Dept Intervent Neuroradiol, TiantanXili 6, Beijing 100050, Peoples R China;重点科室医技科室研究所放射科放射科北京市神经外科研究所首都医科大学附属天坛医院[2]Capital Med Univ, Beijing Tian Tan Hosp, TiantanXili 6, Beijing 100050, Peoples R China;[3]Univ Buffalo State Univ New York, Toshiba Stroke & Vasc Res Ctr, Buffalo, NY 14214 USA;[4]Univ Buffalo State Univ New York, Dept Mech & Aerosp Engn, Buffalo, NY 14214 USA;[5]Fudan Univ, Dept Engn Sci & Mech, 220 Handan Rd, Shanghai 200433, Peoples R China;[6]Univ Buffalo State Univ New York, Dept Neurosurg, Buffalo, NY 14214 USA;[7]Univ Buffalo State Univ New York, Dept Radiol, Buffalo, NY 14214 USA
Stent-assisted coiling technology is widely used in the treatment of intracranial aneurysms. However, differences among various stent configurations have not been fully characterized. This study investigates the hemodynamic effects for various stent configurations. Computational fluid dynamics simulations were performed on an idealized wide-neck basilar tip aneurysm model, which was constructed from digital subtraction angiography images with a virtual stenting technique. The orifice of the aneurysm was tilted toward the left posterior cerebral artery (PCA). The right half-Y configuration caused only a small change in the overall intra-aneurysmal flow pattern compared with the pattern produced without a stent. Percentage of hemodynamic changes were all compared to the untreated aneurysm. The values of wall shear stress (WSS) and flow velocity showed reductions of 16.36 and 3.22 %, respectively. Although the Y configuration showed relatively obvious decreases of 56.27 and 33.55 % in WSS and flow velocity, respetively, the left half-Y configuration, which is usually deployed as the first stent clinically, produced a more obvious flow reduction than those of the right half-Y and Y configurations. Consistent decreases in the velocity and WSS were observed. WSS and flow velocity showed reductions of 58.39 and 41.76 %, respectively. The cross-bar configuration showed the highest WSS and flow velocity reductions (58.42 and 46.49 %, respectively). The right half-Y configuration had relative more impacts on the WSS of the right PCoA than the left half-Y configuration. For the Y and cross-bar configurations, the WSS of the right PCA obviously decreased. The overall pressure change was less than 1 % for the various configurations, with the Y configuration having the highest pressure increase (0.728 %). Simulation results demonstrate obvious differences among the various stent configurations in a wide-neck basilar tip aneurysm.
基金:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81571128, 81301003, 81171079, 81371315, 81471167, 81220108007]; Special Research Project for Capital Health Development [2014-1-1071]; National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01 NS091075]
第一作者机构:[1]Capital Med Univ, Beijing Neurosurg Inst, Dept Intervent Neuroradiol, TiantanXili 6, Beijing 100050, Peoples R China;[2]Capital Med Univ, Beijing Tian Tan Hosp, TiantanXili 6, Beijing 100050, Peoples R China;
通讯作者:
通讯机构:[1]Capital Med Univ, Beijing Neurosurg Inst, Dept Intervent Neuroradiol, TiantanXili 6, Beijing 100050, Peoples R China;[2]Capital Med Univ, Beijing Tian Tan Hosp, TiantanXili 6, Beijing 100050, Peoples R China;[5]Fudan Univ, Dept Engn Sci & Mech, 220 Handan Rd, Shanghai 200433, Peoples R China;
推荐引用方式(GB/T 7714):
Wang Chao,Tian Zhongbin,Liu Jian,et al.Hemodynamic Alterations for Various Stent Configurations in Idealized Wide-neck Basilar Tip Aneurysm[J].JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING.2016,36(3):379-385.doi:10.1007/s40846-016-0139-7.
APA:
Wang, Chao,Tian, Zhongbin,Liu, Jian,Jing, Linkai,Paliwal, Nikhil...&Yang, Xinjian.(2016).Hemodynamic Alterations for Various Stent Configurations in Idealized Wide-neck Basilar Tip Aneurysm.JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING,36,(3)
MLA:
Wang, Chao,et al."Hemodynamic Alterations for Various Stent Configurations in Idealized Wide-neck Basilar Tip Aneurysm".JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING 36..3(2016):379-385