详情页 - 首都医科大学宣武医院知识库

当前位置：首页 > 详情页

Identification of a novel transcript of human MD2 gene

文献详情

资源类型：

收录情况： ◇ SCIE

作者：

机构： [1]Capital Med Univ, Beijing Childrens Hosp,Minist Educ,Key Lab Major, Beijing Pediat Res Inst,Natl Key Discipline Pedia, Beijing Key Lab Pediat Resp Infect Dis,Natl Clin, Beijing 100045, Peoples R China; [2]Capital Med Univ, Beijing Childrens Hosp, Beijing Pediat Res Inst, 56 Nanlishi Rd, Beijing 100045, Peoples R China

出处：

DOI：

ISSN：

关键词： Myeloid differentiation protein 2 Lipopolysaccharide Transcript Structure

摘要：

Myeloid differentiation protein 2 (MD2) regulates bacterial lipopolysaccharide (LPS) triggered anti-bacterial immune response as a broker between LPS and Toll-like receptor 4 (TLR4). In this study, we identified a novel naturally occurring spliceosome of human MD2, termed as MD2-T3. This transcript lacked two exons of MD2 gene. By protein structure analysis and literature review, we predicted that MD2-T3 isoform might execute regulatory biological effects such as limiting LPS-triggered TLR4 signaling. (C) 2016 Elsevier B.V. All rights reserved.

基金：

语种：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2015]版：

大类 | 4 区生物

小类 | 4 区遗传学

最新[2023]版：

大类 | 3 区生物学

小类 | 3 区遗传学

JCR分区：

出版当年[2014]版：

Q3 GENETICS & HEREDITY

最新[2023]版：

Q2 GENETICS & HEREDITY

影响因子： 2.6 最新[2023版] 2.7 最新五年平均 2.138 出版当年[2014版] 2.185 出版当年五年平均 2.082 出版前一年[2013版] 2.319 出版后一年[2015版]

第一作者：

第一作者机构： [1]Capital Med Univ, Beijing Childrens Hosp,Minist Educ,Key Lab Major, Beijing Pediat Res Inst,Natl Key Discipline Pedia, Beijing Key Lab Pediat Resp Infect Dis,Natl Clin, Beijing 100045, Peoples R China;

通讯作者：

通讯机构： [1]Capital Med Univ, Beijing Childrens Hosp,Minist Educ,Key Lab Major, Beijing Pediat Res Inst,Natl Key Discipline Pedia, Beijing Key Lab Pediat Resp Infect Dis,Natl Clin, Beijing 100045, Peoples R China; [2]Capital Med Univ, Beijing Childrens Hosp, Beijing Pediat Res Inst, 56 Nanlishi Rd, Beijing 100045, Peoples R China

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]An investigation of Amphiphysin II transcript expression in pituitary adenomas [2]Multiple effects of curcumin on promoting expression of the exon 7-containing SMN2 transcript [3]Structure-function coupling reveals the brain hierarchical structure dysfunction in Alzheimer's disease: A multicenter study [4]Prolonged Neuroinflammation after Lipopolysaccharide Exposure in Aged Rats [5]The relationship between hypotensive effect and structure of adrenomedullin [6]Hydroxysafflor yellow A attenuate lipopolysaccharide-induced endothelium inflammatory injury [7]长链非编码RNA CRNDE基因不同转录本在胶质瘤组织中的表达差异分析 [8]体制转变中医院面临的矛盾及对策思路 [9]羟基红花黄色素A缓解脂多糖诱导家兔白细胞活化的作用 [10]RNA-seq of 272 gliomas revealed a novel, recurrent PTPRZ1-MET fusion transcript in secondary glioblastomas