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Utility of Shear Wave Elastography for Differentiating Biliary Atresia From Infantile Hepatitis Syndrome

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机构: [1]Capital Med Univ, Beijing Childrens Hosp, Dept Ultrasound, Beijing, Peoples R China; [2]Capital Med Univ, Beijing Friendship Hosp, Dept Ultrasound, 95 Yongan Rd, Beijing 100050, Peoples R China; [3]Childrens Hosp Philadelphia, Dept Radiol, Philadelphia, PA 19104 USA
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关键词: biliary atresia infant infantile hepatitis syndrome pediatric ultrasound shear wave elastography sonography

摘要:
Objectives-The purpose of this study was to investigate the potential utility of shear wave elastography (SWE) for diagnosis of biliary atresia and for differentiating biliary atresia from infantile hepatitis syndrome by measuring liver stiffness. Methods-Thirty-eight patients with biliary atresia and 17 patients with infantile hepatitis syndrome were included, along with 31 healthy control infants. The 3 groups underwent SWE. The hepatic tissue of each patient with biliary atresia had been surgically biopsied. Statistical analyses for mean values of the 3 groups were performed. Optimum cutoff values using SWE for differentiation between the biliary atresia and control groups were calculated by a receiver operating characteristic (ROC) analysis. Results-The mean SWE values +/- SD for the 3 groups were as follows: biliary atresia group, 20.46 +/- 10.19 kPa; infantile hepatitis syndrome group, 6.29 +/- 0.99 kPa; and control group, 6.41 +/- 1.08 kPa. The mean SWE value for the biliary atresia group was higher than the values for the control and infantile hepatitis syndrome groups (P<.01). The mean SWE values between the control and infantile hepatitis syndrome groups were not statistically different. The ROC analysis showed a cutoff value of 8.68 kPa for differentiation between the biliary atresia and control groups. The area under the ROC curve was 0.997, with sensitivity of 97.4%, specificity of 100%, a positive predictive value of 100%, and a negative predictive value of 96.9%. Correlation analysis suggested a positive correlation between SWE values and age for patients with biliary atresia, with a Pearson correlation coefficient of 0.463 (P<.05). Conclusions-The significant increase in liver SWE values in neonates and infants with biliary atresia supports their application for differentiating biliary atresia from infantile hepatitis syndrome.

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出版当年[2015]版:
大类 | 4 区 医学
小类 | 3 区 声学 4 区 核医学
最新[2023]版:
大类 | 4 区 医学
小类 | 3 区 声学 4 区 核医学
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出版当年[2014]版:
Q2 ACOUSTICS Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2023]版:
Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Q2 ACOUSTICS

影响因子: 最新[2023版] 最新五年平均 出版当年[2014版] 出版当年五年平均 出版前一年[2013版] 出版后一年[2015版]

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第一作者机构: [2]Capital Med Univ, Beijing Friendship Hosp, Dept Ultrasound, 95 Yongan Rd, Beijing 100050, Peoples R China;
通讯作者:
通讯机构: [2]Capital Med Univ, Beijing Friendship Hosp, Dept Ultrasound, 95 Yongan Rd, Beijing 100050, Peoples R China;
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