Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a unique circulating phospholipase with inflammatory and oxidative activities and the limited data regarding the relationship between Lp-PLA(2) and cognitive impairment are conflicted. We conducted a cross-sectional study including 1,374 Chinese adults recruited from 2010 to 2011, aiming to evaluate the relationship between Lp-PLA(2) levels and the prevalence of cognitive impairment in a Chinese community-based population. Participants underwent standardized evaluation. Serum Lp-PLA(2) mass was measured by ELISA. Cognition status was evaluated via the Mini-Mental Status Exam (MMSE) and cognitive impairment was identified as MMSE <24. Multivariable logistic regression models were used to assess the associations of Lp-PLA(2) mass with cognitive impairment. Lp-PLA(2) mass was significantly associated with the prevalence of cognitive impairment after adjusting for other potential confounding factors (compared with the first quartile, adjusted ORs of the second, third, and fourth quartile were 2.058 (95% CI, 0.876-4.835), 2.834 (95% CI, 1.255-6.398), and 4.882 (95% CI, 2.212-10.777), p < 0.0001). In conclusion, elevated level of Lp-PLA(2) mass was independently associated with the prevalence of cognitive impairment in Chinese adults.
基金：
Beijing Medical High Level Academic Leader [2014-2-010]; Beijing Municipal Administration of Hospitals'Dengfeng Plan [DFL20150501]; Beijing Municipal Science & Technology CommissionBeijing Municipal Science & Technology Commission
第一作者机构：[1]Capital Med Univ, Beijing Tian Tan Hosp, Dept Neurol, Beijing 100050, Peoples R China;[2]China Natl Clin Res Ctr Neurol Dis, Beijing 100050, Peoples R China;[3]Beijing Inst Brain Disorders, Ctr Stroke, Beijing 100050, Peoples R China;[4]Beijing Key Lab Translat Med Cerebrovasc Dis, Beijing 100050, Peoples R China;
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Tian Tan Hosp, Dept Neurol, Beijing 100050, Peoples R China;[2]China Natl Clin Res Ctr Neurol Dis, Beijing 100050, Peoples R China;[3]Beijing Inst Brain Disorders, Ctr Stroke, Beijing 100050, Peoples R China;[4]Beijing Key Lab Translat Med Cerebrovasc Dis, Beijing 100050, Peoples R China;[5]North China Univ Sci & Technol, Kailuan Hosp, Dept Cardiol, Tangshan 063000, Peoples R China;
推荐引用方式(GB/T 7714)：
Jiang Ruixuan,Chen Shengyun,Shen Yuan,et al.Higher Levels of Lipoprotein Associated Phospholipase A2 is associated with Increased Prevalence of Cognitive Impairment: the APAC Study[J].SCIENTIFIC REPORTS.2016,6:-.doi:10.1038/srep33073.
APA：
Jiang, Ruixuan,Chen, Shengyun,Shen, Yuan,Wu, Jianwei,Chen, Shuohua...&Zhao, Xingquan.(2016).Higher Levels of Lipoprotein Associated Phospholipase A2 is associated with Increased Prevalence of Cognitive Impairment: the APAC Study.SCIENTIFIC REPORTS,6,
MLA：
Jiang, Ruixuan,et al."Higher Levels of Lipoprotein Associated Phospholipase A2 is associated with Increased Prevalence of Cognitive Impairment: the APAC Study".SCIENTIFIC REPORTS 6.(2016):-
