Purpose: Here we present our experience with five cerebral proliferative angiopathy (CPA) patients to better delineate the clinical and angiographic features as well as the treatment selection of this disease. Methods: Between October 2008 and October 2012, five consecutive patients diagnosed with CPA were admitted to our department in our hospital. All the five patients received magnetic resonance imaging, digital subtraction angiography, and positron emission computed tomography (PET) to definitively confirm this disease. We also collected 15 previously published instances of CPA to analyze the characteristics of this rare entity. Results: As to the five patients, three were female and two were male, between the ages of 4 and 52 years with a mean age of 24.8 +/- 20.6 years. The PET results showed that perfusion was decreased over the affected hemispheres in all five patients. As to the treatment, only one patient received encephalo-duro-arterio-synangiosis (EDAS) revascularization surgery. The other four patients were conservatively observed. During the follow-up period (range 3-6 years, mean 4 +/- 1.9 years), the patient who underwent EDAS surgery manifested relief of clinical symptoms. In the conservative series, the symptoms in two patients aggravated and suffered permanent neurologic deficits. Conclusion: CPA is a rare entity. Natural history has showed this disease is not stable and may progress at a certain time point. The EDAS procedure may be a treatment for CPA-related oligemia since there is currently little data and follow-up available.
基金：
Commission of Beijing Municipal Science and Technology [Z14110000211441]; National Natural Science FoundationNational Natural Science Foundation of China [81171078]; Beijing Talents Training Project (Category D); Beijing Hygiene System High-level Hygienic Technical Personnel Training Program; Talents Program of Beijing Tiantan Hospital (Hospital Backbone Program)
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
大类|4 区医学
小类|4 区临床神经病学4 区核医学
最新[2023]版：
大类|4 区医学
小类|4 区临床神经病学4 区核医学
JCR分区：
出版当年[2014]版：
Q4CLINICAL NEUROLOGYQ4RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2023]版：
Q3CLINICAL NEUROLOGYQ3RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ4CLINICAL NEUROLOGY
第一作者机构：[1]Capital Med Univ, Beijing Neurosurg Inst, Intervent Neuroradiol Dept, Beijing, Peoples R China;[2]Capital Med Univ, Beijing Tiantan Hosp, Beijing, Peoples R China;[3]Capital Med Univ, Beijing Neurosurg Inst, Beijing Tiantan Hosp, 6 Tiantan Xili, Beijing 100050, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Neurosurg Inst, Intervent Neuroradiol Dept, Beijing, Peoples R China;[2]Capital Med Univ, Beijing Tiantan Hosp, Beijing, Peoples R China;[3]Capital Med Univ, Beijing Neurosurg Inst, Beijing Tiantan Hosp, 6 Tiantan Xili, Beijing 100050, Peoples R China
推荐引用方式(GB/T 7714)：
Liu Peng,Lv Xianli,Lv Ming,et al.Cerebral proliferative angiopathy: Clinical, angiographic features and literature review[J].INTERVENTIONAL NEURORADIOLOGY.2016,22(1):101-107.doi:10.1177/1591019915609784.
APA：
Liu, Peng,Lv, Xianli,Lv, Ming&Li, Youxiang.(2016).Cerebral proliferative angiopathy: Clinical, angiographic features and literature review.INTERVENTIONAL NEURORADIOLOGY,22,(1)
MLA：
Liu, Peng,et al."Cerebral proliferative angiopathy: Clinical, angiographic features and literature review".INTERVENTIONAL NEURORADIOLOGY 22..1(2016):101-107
