The extracellular space (ECS) in the brain provides an extrasynaptic transfer channel among neurons, axons and glial cells. It is particularly important in the early stage after birth, when angiogenesis is not yet complete and the ECS may provide the main pathway for metabolite transport. However, the characteristics of extracellular transport remain unclear. In this study, a novel magnetic resonance imaging (MRI) method was used to perform real-time visualization and quantification of diffusion in the brain ECS of infant (postnatal day 10 (P10)) and adult rats. Using a modified diffusion equation and the linear relationship between the signal intensity and the gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA) concentration, diffusion parameters were obtained; these parameters include the effective diffusion coefficient (D*), clearance rate (k'), tortuosity (lambda) and the volume fraction of distribution (Vd%). There were significant differences in the diffusion parameters between P10 and adult rats. This finding provides a reference for future treatment of brain diseases using drugs administered via interstitial pathways. (C) 2016 ISDN. Published by Elsevier Ltd. All rights reserved.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [31271161, 81471633]
第一作者机构：[1]Capital Med Univ, Beijing Childrens Hosp, Imaging Ctr, 56 Nanlishi Rd, Beijing 100045, Peoples R China;
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Childrens Hosp, Imaging Ctr, 56 Nanlishi Rd, Beijing 100045, Peoples R China;[4]Peking Univ, Hosp 3, Dept Radiol, 49 North Huayuan Rd, Beijing 100191, Peoples R China;[5]Beijing Key Lab Magnet Resonance Imaging Device &, Beijing 100191, Peoples R China
推荐引用方式(GB/T 7714)：
Yang Shuangfeng,Wang Yan,Li Kai,et al.Extracellular space diffusion analysis in the infant and adult rat striatum using magnetic resonance imaging[J].INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE.2016,53:1-7.doi:10.1016/j.ijdevneu.2016.05.009.
APA：
Yang, Shuangfeng,Wang, Yan,Li, Kai,Tang, Xiaolu,Zhang, Kuo...&Peng, Yun.(2016).Extracellular space diffusion analysis in the infant and adult rat striatum using magnetic resonance imaging.INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE,53,
MLA：
Yang, Shuangfeng,et al."Extracellular space diffusion analysis in the infant and adult rat striatum using magnetic resonance imaging".INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE 53.(2016):1-7
