A novel cell cycle-associated IncRNA, HOXA11-AS, is transcribed from the 5-prime end of the HOXA transcript and is a biomarker of progression in glioma
The comprehensive incRNA expression signature in glioma has not yet been fully elucidated. We performed a high-throughput microarray to detect the ncRNA expression profiles of 220 human glioma tissues. Here, we found that a novel IncRNA, HOXA11-AS, was the antisense transcript of the HOX11 gene. It was shown that HOXA11-AS was closely associated with glioma grade and poor prognosis. Multivariate Cox regression analysis revealed that HOXA11-AS was an independent prognostic factor in glioblastoma multiforme patients, and its expression was correlated with the glioma molecular subtypes of the Cancer Genome Atlas. Gene set enrichment analysis indicated that the gene sets most correlated with HOXA11-AS expression were involved in cell cycle progression. Over-expression of the HOXA11-AS transcript promoted cell proliferation in vitro, while knockdown of HOXA11-AS expression repressed cell proliferation via regulation of cell cycle progression. The growth-promoting and growth-inhibiting effects of HOXA11-AS were also demonstrated in a xenograft mouse model. Our data confirms, for the first time, that HOXA11-AS is an important long non-coding RNA that primarily serves as a prognostic factor for glioma patient survival. HOXA11-AS could serve as a biomarker for identifying glioma molecular subtypes and as therapeutic target for glioma patients. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
基金：
National High Technology Research and Development Program 863National High Technology Research and Development Program of China [2014AA021102]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81572496, 81572932, 81502619]
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外文
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出版当年[2015]版：
大类|2 区医学
小类|2 区肿瘤学
最新[2023]版：
大类|1 区医学
小类|2 区肿瘤学
第一作者：
第一作者机构：[1]Tianjin Med Univ, Gen Hosp, Dept Neurosurg, Tianjin 300052, Peoples R China;[2]Tianjin Neurol Inst, Lab Neurooncol, Tianjin 300052, Peoples R China;[3]Minist Educ, Key Lab Posttrauma Neurorepair & Regenerat Cent N, Tianjin 300052, Peoples R China;[4]Tianjin Key Lab Injuries Variat & Regenerat Nervo, Tianjin 300052, Peoples R China;[5]CGCG, 6 Tiantanxi Li, Beijing 100050, Peoples R China;
通讯作者：
通讯机构：[1]Tianjin Med Univ, Gen Hosp, Dept Neurosurg, Tianjin 300052, Peoples R China;[2]Tianjin Neurol Inst, Lab Neurooncol, Tianjin 300052, Peoples R China;[3]Minist Educ, Key Lab Posttrauma Neurorepair & Regenerat Cent N, Tianjin 300052, Peoples R China;[4]Tianjin Key Lab Injuries Variat & Regenerat Nervo, Tianjin 300052, Peoples R China;[5]CGCG, 6 Tiantanxi Li, Beijing 100050, Peoples R China;
推荐引用方式(GB/T 7714)：
Wang Qixue,Zhang Junxia,Liu Yanwei,et al.A novel cell cycle-associated IncRNA, HOXA11-AS, is transcribed from the 5-prime end of the HOXA transcript and is a biomarker of progression in glioma[J].CANCER LETTERS.2016,373(2):251-259.doi:10.1016/j.canlet.2016.01.039.
APA：
Wang, Qixue,Zhang, Junxia,Liu, Yanwei,Zhang, Wei,Zhou, Junhu...&Han, Lei.(2016).A novel cell cycle-associated IncRNA, HOXA11-AS, is transcribed from the 5-prime end of the HOXA transcript and is a biomarker of progression in glioma.CANCER LETTERS,373,(2)
MLA：
Wang, Qixue,et al."A novel cell cycle-associated IncRNA, HOXA11-AS, is transcribed from the 5-prime end of the HOXA transcript and is a biomarker of progression in glioma".CANCER LETTERS 373..2(2016):251-259
医学