Low expressions of ARS2 and CASP8AP2 predict relapse and poor prognosis in pediatric acute lymphoblastic leukemia patients treated on China CCLG-ALL 2008 protocol
ARS2 protein is important to early development and cell proliferation, in which ARS2-CASP8AP2 interaction is implicated. However, the predictive significance of ARS2 in childhood acute lymphoblastic leukemia (ALL) is unknown. Here we evaluate the predictive values of ARS2 expression and combined ARS2 and CASP8AP2 expression in relapse. We showed that ARS2 expression in ALL bone marrow samples at initial diagnosis was markedly lower than that in complete remission (CR). Likewise, the levels of ARS2 expression in the patients suffering from relapse were significantly lower than that of patients in continuous CR. Furthermore, low expression of ARS2 was closely correlated to poor treatment response including poor prednisone response and high minimal residual disease (MRD), and the patients with high MRD (>10-4) and low ARS2 were more subject to relapse. The multivariate analyses for relapse free survival and event free survival revealed that ARS2 expression remained an independent prognostic factor after adjusting other risk factors. In addition, combined assessment of ARS2 and CASP8AP2 expression was more accurate to predict relapse, based on which an algorithm composed of ARS2 and CASP8AP2 expression, prednisone response and MRD (day 78) was proposed. Together, ARS2 and CASP8AP2 expressions can precisely predict high-risk of relapse and ALL prognosis. (C) 2014 Elsevier Ltd. All rights reserved.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81200392, 81170504]; Beijing Health Qualified Personnel Program [2011-3-049]; Technological Projects of Beijing Municipal Education Commission [KZ201210025031]; Beijing National Science Foundation [7152054]; National Key Technologies Research & Development Program of the 11th 5-Year Plan [2007BAI04B03]; Beijing Municipal Administration of Hospitals Clinical medicine Development of special funding [ZY201404]
第一作者机构：[1]Capital Med Univ, Dept Biochem & Mol Biol, Sch Basic Med Sci, Beijing 100069, Peoples R China;[2]Capital Med Univ, Beijing Key Lab Pediat Hematol Oncol, Key Lab Major Dis Children,Beijing Childrens Hosp, Natl Key Discipline Pediat,Minist Educ,Hematol On, Beijing 100069, Peoples R China;
通讯作者：
通讯机构：[1]Capital Med Univ, Dept Biochem & Mol Biol, Sch Basic Med Sci, Beijing 100069, Peoples R China;[4]Capital Med Univ, Dept Biochem & Mol Biol, Sch Basic Med Sci, 10 Youan Men, Beijing 100069, Peoples R China
推荐引用方式(GB/T 7714)：
Cui Lei,Gao Chao,Zhang Rui-Dong,et al.Low expressions of ARS2 and CASP8AP2 predict relapse and poor prognosis in pediatric acute lymphoblastic leukemia patients treated on China CCLG-ALL 2008 protocol[J].LEUKEMIA RESEARCH.2015,39(2):115-123.doi:10.1016/j.leukres.2014.10.008.
APA：
Cui, Lei,Gao, Chao,Zhang, Rui-Dong,Jiao, Ying,Li, Wei-Jing...&Jia, Hong-Ti.(2015).Low expressions of ARS2 and CASP8AP2 predict relapse and poor prognosis in pediatric acute lymphoblastic leukemia patients treated on China CCLG-ALL 2008 protocol.LEUKEMIA RESEARCH,39,(2)
MLA：
Cui, Lei,et al."Low expressions of ARS2 and CASP8AP2 predict relapse and poor prognosis in pediatric acute lymphoblastic leukemia patients treated on China CCLG-ALL 2008 protocol".LEUKEMIA RESEARCH 39..2(2015):115-123
