机构：[1]Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China. ; Key Laboratory on Brain Function Repair and Regeneration of Guangdong, Southern Medical University, Guangzhou, China.[2]Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.[3]Neuroscience Research Institute of North Carolina, Winston-Salem, NC, USA.[4]Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China. ; Key Laboratory on Brain Function Repair and Regeneration of Guangdong, Southern Medical University, Guangzhou, China. ; Department of Neurosurgery, The Military General Hospital of Beijing PLA, Beijing, China.
The aim of this study was to investigate voluntary wheel running behavior in the unilateral 6-hydroxydopamine (6-OHDA) rat model.
Male Sprague-Dawley rats were assigned to 2 groups : 6-OHDA group (n=17) and control group (n=8). The unilateral 6-OHDA rat model was induced by injection of 6-OHDA into unilateral medial forebrain bundle using a stereotaxic instrument. Voluntary wheel running activity was assessed per day in successfully lesioned rats (n=10) and control rats. Each behavioral test lasted an hour. The following parameters were investigated during behavioral tests : the number of running bouts, the distance moved in the wheel, average peak speed in running bouts and average duration from the running start to the peak speed.
The number of running bouts and the distance moved in the wheel were significantly decreased in successfully lesioned rats compared with control rats. In addition, average peak speed in running bouts was decreased, and average duration from the running start to the peak speed was increased in lesioned animals, which might indicate motor deficits in these rats. These behavioral changes were still observed 42 days after lesion.
Voluntary wheel running behavior is impaired in the unilateral 6-OHDA rat model and may represent a useful tool to quantify motor deficits in this model.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
大类|4 区医学
小类|4 区临床神经病学4 区外科
最新[2023]版：
大类|4 区医学
小类|4 区临床神经病学4 区外科
第一作者：
第一作者机构：[1]Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China. ; Key Laboratory on Brain Function Repair and Regeneration of Guangdong, Southern Medical University, Guangzhou, China.
推荐引用方式(GB/T 7714)：
Pan Qi,Zhang Wangming,Wang Jinyan,et al.Impaired voluntary wheel running behavior in the unilateral 6-hydroxydopamine rat model of Parkinson's disease.[J].Journal of Korean Neurosurgical Society.2015,57(2):82-7.doi:10.3340/jkns.2015.57.2.82.
APA：
Pan Qi,Zhang Wangming,Wang Jinyan,Luo Fei,Chang Jingyu&Xu Ruxiang.(2015).Impaired voluntary wheel running behavior in the unilateral 6-hydroxydopamine rat model of Parkinson's disease..Journal of Korean Neurosurgical Society,57,(2)
MLA：
Pan Qi,et al."Impaired voluntary wheel running behavior in the unilateral 6-hydroxydopamine rat model of Parkinson's disease.".Journal of Korean Neurosurgical Society 57..2(2015):82-7
