机构:[1]Capital Med Univ, Beijing Tian Tan Hosp, Dept Neurol, Beijing 100050, Peoples R China;[2]China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China;国家神经系统疾病临床医学研究中心国家神经系统疾病临床医学研究中心首都医科大学附属天坛医院[3]Capital Med Univ, Beijing Tian Tan Hosp, Dept Nephrol, Beijing 100050, Peoples R China;[4]Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China;[5]Capital Med Univ, Beijing Tian Tan Hosp, Dept Neurol, 6 Tiantan Xili, Beijing 100050, Peoples R China
Background: Leukoaraiosis (LA) is an indicator of small vessel disease, but little is known about the relationship between the severity of LA and etiologic subtype of ischemic stroke. Our study aimed to investigate the factors associated with the severity of LA and the relationship between the severity of LA and etiologic subtype of ischemic stroke. Methods: A total of 791 patients with first-ever ischemic stroke within 7 days were enrolled in our study. We evaluated cranial magnetic resonance imagings including severity of LA in periventricular and deep white matter, severity of silent lacunar infarcts (SLIs), etiologic subtype of ischemic stroke, and topographic patterns of acute cerebral infarcts. Severity of LA was graded as grade 0 when Fazekas scores = 0, grade 1 when Fazekas scores ranged from 1 to 2, and grade 2 when Fazekas scores were greater than or equal to 3. Multivariable ordinal logistic regression was used to analyze the factors associated with the severity of LA. Results: A total of 748 patients (94.6%) had LA, the numbers and proportions of grade 0, grade 1, and grade 2 LA were 43 patients (5.4%), 413 patients (52.2%), and 335 patients (42.4%), respectively. In multivariable ordinal logistic regression analysis, increasing age, higher diastolic blood pressure, admission National Institutes of Health Stroke Scale scores less than or equal to 3, presence of SLIs, and small artery occlusion (SAO) subtype of ischemic stroke were found to be independently associated with higher grade of LA. Conclusions: LA is prevalent in first-ever ischemic stroke patients. Severe LA is more frequently associated with higher grades of SLIs and ischemic stroke due to SAO.
基金:
Ministry of Science and Technology of the People's Republic of ChinaMinistry of Science and Technology, China [2013BAI09B03, 2012ZX09303-005-001, 2011BAI08B02]; S.H. Ho Cardiovascular Disease and Stroke Center of the Chinese University of Hong Kong
第一作者机构:[1]Capital Med Univ, Beijing Tian Tan Hosp, Dept Neurol, Beijing 100050, Peoples R China;[2]China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China;
通讯作者:
通讯机构:[1]Capital Med Univ, Beijing Tian Tan Hosp, Dept Neurol, Beijing 100050, Peoples R China;[2]China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China;[5]Capital Med Univ, Beijing Tian Tan Hosp, Dept Neurol, 6 Tiantan Xili, Beijing 100050, Peoples R China
推荐引用方式(GB/T 7714):
Zhang Changqing,Wang Yilong,Zhao Xingquan,et al.Factors Associated with Severity of Leukoaraiosis in First-ever Lacunar Stroke and Atherosclerotic Ischemic Stroke Patients[J].JOURNAL OF STROKE & CEREBROVASCULAR DISEASES.2014,23(10):2862-2868.doi:10.1016/j.jstrokecerebrovasdis.2014.07.021.
APA:
Zhang, Changqing,Wang, Yilong,Zhao, Xingquan,Wang, Chunxue,Liu, Liping...&Wang, Yongjun.(2014).Factors Associated with Severity of Leukoaraiosis in First-ever Lacunar Stroke and Atherosclerotic Ischemic Stroke Patients.JOURNAL OF STROKE & CEREBROVASCULAR DISEASES,23,(10)
MLA:
Zhang, Changqing,et al."Factors Associated with Severity of Leukoaraiosis in First-ever Lacunar Stroke and Atherosclerotic Ischemic Stroke Patients".JOURNAL OF STROKE & CEREBROVASCULAR DISEASES 23..10(2014):2862-2868