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Factors Associated with Severity of Leukoaraiosis in First-ever Lacunar Stroke and Atherosclerotic Ischemic Stroke Patients

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机构: [1]Capital Med Univ, Beijing Tian Tan Hosp, Dept Neurol, Beijing 100050, Peoples R China; [2]China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China; [3]Capital Med Univ, Beijing Tian Tan Hosp, Dept Nephrol, Beijing 100050, Peoples R China; [4]Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China; [5]Capital Med Univ, Beijing Tian Tan Hosp, Dept Neurol, 6 Tiantan Xili, Beijing 100050, Peoples R China
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关键词: Leukoaraiosis cerebral infarction cerebral small vessel diseases risk factors

摘要:
Background: Leukoaraiosis (LA) is an indicator of small vessel disease, but little is known about the relationship between the severity of LA and etiologic subtype of ischemic stroke. Our study aimed to investigate the factors associated with the severity of LA and the relationship between the severity of LA and etiologic subtype of ischemic stroke. Methods: A total of 791 patients with first-ever ischemic stroke within 7 days were enrolled in our study. We evaluated cranial magnetic resonance imagings including severity of LA in periventricular and deep white matter, severity of silent lacunar infarcts (SLIs), etiologic subtype of ischemic stroke, and topographic patterns of acute cerebral infarcts. Severity of LA was graded as grade 0 when Fazekas scores = 0, grade 1 when Fazekas scores ranged from 1 to 2, and grade 2 when Fazekas scores were greater than or equal to 3. Multivariable ordinal logistic regression was used to analyze the factors associated with the severity of LA. Results: A total of 748 patients (94.6%) had LA, the numbers and proportions of grade 0, grade 1, and grade 2 LA were 43 patients (5.4%), 413 patients (52.2%), and 335 patients (42.4%), respectively. In multivariable ordinal logistic regression analysis, increasing age, higher diastolic blood pressure, admission National Institutes of Health Stroke Scale scores less than or equal to 3, presence of SLIs, and small artery occlusion (SAO) subtype of ischemic stroke were found to be independently associated with higher grade of LA. Conclusions: LA is prevalent in first-ever ischemic stroke patients. Severe LA is more frequently associated with higher grades of SLIs and ischemic stroke due to SAO.

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出版当年[2013]版:
大类 | 4 区 医学
小类 | 4 区 神经科学 4 区 外周血管病
最新[2023]版:
大类 | 4 区 医学
小类 | 4 区 神经科学 4 区 外周血管病
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出版当年[2012]版:
Q3 NEUROSCIENCES Q3 PERIPHERAL VASCULAR DISEASE
最新[2023]版:
Q3 NEUROSCIENCES Q3 PERIPHERAL VASCULAR DISEASE

影响因子: 最新[2023版] 最新五年平均 出版当年[2012版] 出版当年五年平均 出版前一年[2011版] 出版后一年[2013版]

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第一作者机构: [1]Capital Med Univ, Beijing Tian Tan Hosp, Dept Neurol, Beijing 100050, Peoples R China; [2]China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China;
通讯作者:
通讯机构: [1]Capital Med Univ, Beijing Tian Tan Hosp, Dept Neurol, Beijing 100050, Peoples R China; [2]China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China; [5]Capital Med Univ, Beijing Tian Tan Hosp, Dept Neurol, 6 Tiantan Xili, Beijing 100050, Peoples R China
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