Objective. Previous studies have demonstrated that stroke characteristics and social and psychological factors jointly contribute to the development of poststroke depression (PSD). The purpose of this study was to identify altered functional connectivity (FC) of the affective network (AN) in patients with PSD and to explore the correlation between FC and the severity of PSD. Materials and Methods. 26 PSD patients, 24 stroke patients without depression, and 24 age-matched normal controls underwent the resting-state functional MRI (fMRI) scanning. The bilateral anterior cingulated cortices (ACCs) were selected as regions of interest (ROIs). FC was calculated and compared among the three groups. The association between FC and Hamilton Depression Rate Scale (HDRS) scores of PSD group was investigated. Results. The FC of the AN was disrupted in PSD patients compared to stroke patients without depression and normal controls. Moreover, the left orbital part of inferior frontal gyrus which indicated altered FC was significantly correlated with HDRS scores in PSD patients. Conclusions. Dysfunction of the affective network may be one of the reasons of the development of PSD.
基金：
State Key Program of National Natural Science of ChinaNational Natural Science Foundation of China [30930031]
语种：
外文
被引次数：
WOS：
PubmedID：
JCR分区：
出版当年[2012]版：
无
最新[2023]版：
Q3BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ3MEDICINE, RESEARCH & EXPERIMENTAL
第一作者机构：[1]Capital Med Univ, Beijing Tiantan Hosp, Dept Neuroradiol, Beijing 100050, Peoples R China;
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Tiantan Hosp, Dept Neuroradiol, Beijing 100050, Peoples R China;[7]Capital Med Univ, Beijing Tiantan Hosp, Dept Neuroradiol, 6 Tiantanxili, Beijing 100050, Peoples R China
推荐引用方式(GB/T 7714)：
Zhang Peiyao,Xu Qin,Dai Jianping,et al.Dysfunction of Affective Network in Post Ischemic Stroke Depression: A Resting-State Functional Magnetic Resonance Imaging Study[J].BIOMED RESEARCH INTERNATIONAL.2014,2014:-.doi:10.1155/2014/846830.
APA：
Zhang, Peiyao,Xu, Qin,Dai, Jianping,Wang, Jun,Zhang, Ning&Luo, Yuejia.(2014).Dysfunction of Affective Network in Post Ischemic Stroke Depression: A Resting-State Functional Magnetic Resonance Imaging Study.BIOMED RESEARCH INTERNATIONAL,2014,
MLA：
Zhang, Peiyao,et al."Dysfunction of Affective Network in Post Ischemic Stroke Depression: A Resting-State Functional Magnetic Resonance Imaging Study".BIOMED RESEARCH INTERNATIONAL 2014.(2014):-
