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Curative Glubran 2 Embolization of Cerebral Arteriovenous Malformations Patient Selection and Initial Results

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机构: [1]Capital Med Univ, Beijing Neurosurg Inst, Intervent Neuroradiol Dept, Beijing, Peoples R China; [2]Capital Med Univ, Beijing Tiantan Hosp, Beijing, Peoples R China; [3]Capital Med Univ, Beijing Neurosurg Inst, Beijing, Peoples R China; [4]Capital Med Univ, Beijing Tiantan Hosp, Beijing, Peoples R China; [5]Beijing Neurosurg Inst, 6 Tiantan Xili, Beijing 100050, Peoples R China
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关键词: arteriovenous malformation cerebral curative embolization embolization Glubran 2

摘要:
The liquid embolic agents currently used for embolization of cerebral arterio venous malformations are Onyx and NB CA. Glubran 2, a cyanoacrylate-based synthetic glue, has recently been applied for embolization of cerebral arterio venous malformations (AVMs). We report the clinical results of selected cerebral AVMs treated with Glubran 2 targeting for curative embolization. Between October 2011 and March 2013, 31 patients with cerebral AVMs were selected for curative embolization with Glubran 2. There were 19 men and 12 women with a mean age of 32 years (range 4 65 years). Initial clinical presentation included hemorrhage in 28 and seizures in three patients. AVM location was frontal in eight patients, parietal in four, occipital in eight temporal in six, cerebellar in two and cerebellar vermis in three patients. Follow-up was performed clinically and with angiography examination at three to six months. Clinical outcomes were evaluated based on the modified Rankin Scale (mRS). A mean of 2.5 (range, 1-12) feeding pedicles were embolized per patient. Complete angiographic obliteration of AVM was achieved in 27 patients. A hemorrhagic complication was observed in one patient, an ischemic complication in one patient and technical complications in four patients. There was no procedure-related disabling neurological deficit or death at discharge. Additional gamma knife radiosurgery was performed in five patients, including one patient with recurrent AVM. All of the patients had favorable clinical outcomes at three to six month follow-up (mRS <= 2). The curative embolization technique with Glubran 2 for selected cerebral AVMs achieved a high initial complete obliteration rate with an acceptable complication frequency.

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出版当年[2013]版:
大类 | 4 区 医学
小类 | 4 区 临床神经病学 4 区 核医学
最新[2023]版:
大类 | 4 区 医学
小类 | 4 区 临床神经病学 4 区 核医学
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出版当年[2012]版:
Q4 CLINICAL NEUROLOGY Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2023]版:
Q3 CLINICAL NEUROLOGY Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Q4 CLINICAL NEUROLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2012版] 出版当年五年平均 出版前一年[2011版] 出版后一年[2013版]

第一作者:
第一作者机构: [1]Capital Med Univ, Beijing Neurosurg Inst, Intervent Neuroradiol Dept, Beijing, Peoples R China; [2]Capital Med Univ, Beijing Tiantan Hosp, Beijing, Peoples R China; [3]Capital Med Univ, Beijing Neurosurg Inst, Beijing, Peoples R China; [4]Capital Med Univ, Beijing Tiantan Hosp, Beijing, Peoples R China; [5]Beijing Neurosurg Inst, 6 Tiantan Xili, Beijing 100050, Peoples R China
通讯作者:
通讯机构: [1]Capital Med Univ, Beijing Neurosurg Inst, Intervent Neuroradiol Dept, Beijing, Peoples R China; [2]Capital Med Univ, Beijing Tiantan Hosp, Beijing, Peoples R China; [3]Capital Med Univ, Beijing Neurosurg Inst, Beijing, Peoples R China; [4]Capital Med Univ, Beijing Tiantan Hosp, Beijing, Peoples R China; [5]Beijing Neurosurg Inst, 6 Tiantan Xili, Beijing 100050, Peoples R China
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