Previous studies have demonstrated that the sonic hedgehog (Shh) pathway plays a neuro-protective role. However, whether the Shh pathway is induced by subarachnoid hemorrhage (SAH) has not been investigated. We sought to investigate Shh activation in the cortex in the early stage of SAH, and assessed the effect of cyclopamine (a specific inhibitor of the Shh pathway) on Shh pathway regulation and evaluated the impact of cyclopamine on SAH. We found that the Shh pathway was up-regulated in the cortex after SAH, and that blocking the Shh pathway increased cell apoptosis. Early brain damages, including brain edema, blood-brain barrier impairment, and cortical apoptosis were significantly aggravated following with cyclopamine treatment compared with vehicle treatment. Our results suggest that the Shh pathway should be activated in the brain after SAH, and plays a beneficial role in SAH development, possibly by inhibiting cerebral oxidative stress through induction of antioxidant and detoxifying enzymes. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
第一作者机构：[1]Capital Med Univ, Beijing Tiantan Hosp, Beijing 100050, Peoples R China;[2]Dalian Med Univ, Hosp 1, Dalian 116021, Peoples R China;
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Tiantan Hosp, Beijing 100050, Peoples R China;
推荐引用方式(GB/T 7714)：
Li Tao,Zhang Jie,Liu Rong-Yao,et al.The role of the sonic hedgehog signaling pathway in early brain injury after experimental subarachnoid hemorrhage in rats[J].NEUROSCIENCE LETTERS.2013,552:81-86.doi:10.1016/j.neulet.2013.07.042.
APA：
Li, Tao,Zhang, Jie,Liu, Rong-Yao,Lian, Zhi-Gang,Chen, Xiao-Lin...&Zhao, Yuan-Li.(2013).The role of the sonic hedgehog signaling pathway in early brain injury after experimental subarachnoid hemorrhage in rats.NEUROSCIENCE LETTERS,552,
MLA：
Li, Tao,et al."The role of the sonic hedgehog signaling pathway in early brain injury after experimental subarachnoid hemorrhage in rats".NEUROSCIENCE LETTERS 552.(2013):81-86
