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Survey of atherosclerotic disease in Asian subjects with cardiovascular disease risk factors who were not receiving lipid-lowering agents

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机构: [1]Seoul Natl Univ Hosp, Seoul 110744, South Korea; [2]Indonesian Heart Assoc, Natl Cardiovasc Ctr Harapan Kita, Jakarta, Indonesia; [3]Capital Med Univ, Beijing Tiantan Hosp, Beijing, Peoples R China; [4]Univ Philippines, Coll Med, Philippine Heart Assoc, Manila, Philippines; [5]Chulalongkorn Univ, Chulalongkorn Mem Hosp, Bangkok, Thailand; [6]Vietnam Natl Heart Inst, Hanoi, Vietnam; [7]Chang Gung Mem Hosp, Linkou Med Ctr, Tao Yuan, Taiwan; [8]Univ Malaysia Sarawak, Sarawak Gen Hosp, Ctr Heart, Kuching, Malaysia; [9]AstraZeneca, Osaka, Japan; [10]AstraZeneca, Singapore, Singapore; [11]Seoul Natl Univ, Seoul Natl Univ Hosp, Coll Med, 101 Daehakro, Seoul 110744, South Korea
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关键词: Carotid intima media thickness Atherosclerosis Cardiovascular disease risk factor Ethnicity Asia

摘要:
Background: Carotid intima media thickness (CIMT) is a surrogate marker for atherosclerosis, used to identify asymptomatic individuals at increased risk of cardiovascular events. The primary objective of this study was to obtain the distribution of CIMT measurements in Asian individuals with cardiovascular disease (CVD) risk factors who were not receiving lipid-lowering agents. Methods: Mean CIMT based on ultrasonographic measurement of 12 sites within the common carotid artery was recorded for 2726 subjects across eight Asian countries who had two or more CVD risk factors but were not receiving lipid-lowering therapy. CVD risk factors and lipid and glucose profiles were analyzed with respect to distribution of CIMT and high-sensitivity C-reactive protein (hs-CRP) values. Results: The overall mean (SD) of mean CIMT (mean-mean CIMT) was 0.662 (0.16) mm. There was a significant variation in mean-mean CIMT across countries (P < 0.0001). Mean-mean CIMT values (mm) by age were: 0.485, 0.527, 0.614, 0.665, 0.715 and 0.797 for <= 29, 30-39, 40-49, 50-59, 60-69 and >= 70 years, respectively. Multivariate analyses confirmed a significant association between increasing mean-mean CIMT and increasing age, male gender, low high-density lipoprotein-cholesterol (HDL-C) levels and elevated fasting blood glucose levels. Analysis of log-transformed hs-CRP levels showed significant association with increasing waist circumference, low-density lipoprotein-cholesterol, body-mass index, high blood glucose levels and low HDL-C. Conclusions: Our data show normative mean-mean CIMT data for Asian subjects with two or more CVD risk factors who are not receiving lipid-lowering therapy, which may guide CVD risk-stratification of asymptomatic individuals in Asia. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

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出版当年[2012]版:
大类 | 2 区 医学
小类 | 2 区 心脏和心血管系统
最新[2023]版:
大类 | 2 区 医学
小类 | 3 区 心脏和心血管系统
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出版当年[2011]版:
Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
最新[2023]版:
Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

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第一作者机构: [1]Seoul Natl Univ Hosp, Seoul 110744, South Korea;
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通讯机构: [1]Seoul Natl Univ Hosp, Seoul 110744, South Korea; [11]Seoul Natl Univ, Seoul Natl Univ Hosp, Coll Med, 101 Daehakro, Seoul 110744, South Korea
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