A 35-year-old man, without any prior history or family history of psychosis, developed psychotic symptoms after starting with low-dose bromocriptine therapy for a macroprolactinoma. Seven days after the initiation of treatment with this medication, the patient suddenly plunged to his death in our hospital without any obvious signs. This case suggests a bromocriptine-induced very serious psychosis in which the patient killed himself without a family history and personal history of psychosis. Therefore, as for all patients with bromocriptine, their mood should be cared after, in case they might commit a suicide. We advise caution in the use of bromocriptine even in patients without a preexisting psychiatric history, and we also recommend that such changes in mental status should be monitored when bromocriptine is prescribed.