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Bushen Yisui Capsule ameliorates axonal injury in experimental autoimmune encephalomyelitis

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收录情况： ◇ SCIE ◇ CSCD-C

作者：

机构： [1]Capital Med Univ, Sch Tradit Chinese Med, Beijing 100069, Peoples R China; [2]Capital Med Univ, Beijing Tiantan Hosp, Beijing 100050, Peoples R China

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关键词： neural regeneration traditional Chinese medicine multiple sclerosis experimental autoimmune encephalomyelitis Bushen Yisui Capsule amyloid precursor protein microtubule-associated protein 2 grants-supported paper neuroregeneration

摘要：

A preliminary clinical study by our group demonstrated Bushen Yisui Capsule (formerly called Erhuang Formula) in combination with conventional therapy is an effective prescription for the treatment of multiple sclerosis. However, its effect on axonal injury during early multiple sclerosis remains unclear. In this study, a MOG(35-55)-immunized C57BL/6 mouse model of experimental autoimmune encephalomyelitis was intragastrically administered Bushen Yisui Capsule. The results showed that Bushen Yisui Capsule effectively improved clinical symptoms and neurological function of experimental autoimmune encephalomyelitis. In addition, amyloid precursor protein expression was down-regulated and microtubule-associated protein 2 was up-regulated. Experimental findings indicate that the disease-preventive mechanism of Bushen Yisui Capsule in experimental autoimmune encephalomyelitis was mediated by amelioration of axonal damage and promotion of regeneration. But the effects of the high-dose Bushen Yisui Capsule group was not better than that of the medium-dose and low-dose Bushen Yisui Capsule group in preventing neurological dysfunction.

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中科院(CAS)分区：

出版当年[2012]版：

大类 | 4 区医学

小类 | 4 区细胞生物学 4 区神经科学

最新[2023]版：

大类 | 2 区医学

小类 | 3 区细胞生物学 3 区神经科学

JCR分区：

出版当年[2011]版：

Q4 CELL BIOLOGY Q4 NEUROSCIENCES

最新[2023]版：

Q1 NEUROSCIENCES Q2 CELL BIOLOGY

影响因子： 5.9 最新[2023版] 5.2 最新五年平均 0.216 出版当年[2011版] 0 出版当年五年平均 0.18 出版前一年[2010版] 0.144 出版后一年[2012版]

第一作者：

第一作者机构： [1]Capital Med Univ, Sch Tradit Chinese Med, Beijing 100069, Peoples R China;

通讯作者：

通讯机构： [1]Capital Med Univ, Sch Tradit Chinese Med, Beijing 100069, Peoples R China;

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