Dual-specificity phosphatases (DUSPs) is an emerging subclass of the protein tyrosine phosphatase gene superfamily, a heterogeneous group of protein phosphatases that can dephosphorylate both phosphotyrosine and phosphoserine/phosphothreonine residues within the one substrate. Recently, a series of investigations of DUSPs defined their essential roles in cell proliferation, cancer and the immune response. This review will focus on DUSP2, its involvement in different diseases and its potential as a therapeutic target. Genes and Immunity (2013) 14, 1-6; doi: 10.1038/gene.2012.54; published online 29 November 2012
基金:
NIAAAUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Alcohol Abuse & Alcoholism (NIAAA) [1R01 AA016342]; NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA; Veterans Administration Medical Center; DNA Discovery Core, University of Tennessee, Memphis, TN
通讯机构:[1]Harbin Med Univ, Ctr Dis Control & Prevent, Ctr Endem Dis Control, Inst Endem Fluorosis Dis, Harbin 150081, Peoples R China;
推荐引用方式(GB/T 7714):
Wei W.,Jiao Y.,Postlethwaite A.,et al.Dual-specificity phosphatases 2: surprising positive effect at the molecular level and a potential biomarker of diseases[J].GENES AND IMMUNITY.2013,14(1):1-6.doi:10.1038/gene.2012.54.
APA:
Wei, W.,Jiao, Y.,Postlethwaite, A.,Stuart, J. M.,Wang, Y....&Gu, W..(2013).Dual-specificity phosphatases 2: surprising positive effect at the molecular level and a potential biomarker of diseases.GENES AND IMMUNITY,14,(1)
MLA:
Wei, W.,et al."Dual-specificity phosphatases 2: surprising positive effect at the molecular level and a potential biomarker of diseases".GENES AND IMMUNITY 14..1(2013):1-6