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Dual-specificity phosphatases 2: surprising positive effect at the molecular level and a potential biomarker of diseases

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收录情况: ◇ SCIE

机构: [1]Harbin Med Univ, Ctr Dis Control & Prevent, Ctr Endem Dis Control, Inst Endem Fluorosis Dis, Harbin 150081, Peoples R China; [2]UTHSC, Campbell Clin, Dept Orthopaed Surg, Memphis, TN 38163 USA; [3]UTHSC, Campbell Clin, Dept BME, Memphis, TN 38163 USA; [4]Mudanjiang Med Coll, Mudanjiang, Peoples R China; [5]UTHSC, Dept Med, Div Connect Tissue Dis, Memphis, TN 38163 USA; [6]Dept Vet Affairs Med Ctr, Memphis, TN USA; [7]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing, Peoples R China
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关键词: dual-specificity phosphatases disease mitogen-activated protein kinase immune

摘要:
Dual-specificity phosphatases (DUSPs) is an emerging subclass of the protein tyrosine phosphatase gene superfamily, a heterogeneous group of protein phosphatases that can dephosphorylate both phosphotyrosine and phosphoserine/phosphothreonine residues within the one substrate. Recently, a series of investigations of DUSPs defined their essential roles in cell proliferation, cancer and the immune response. This review will focus on DUSP2, its involvement in different diseases and its potential as a therapeutic target. Genes and Immunity (2013) 14, 1-6; doi: 10.1038/gene.2012.54; published online 29 November 2012

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出版当年[2012]版:
大类 | 2 区 医学
小类 | 3 区 遗传学 3 区 免疫学
最新[2023]版:
大类 | 3 区 医学
小类 | 3 区 遗传学 4 区 免疫学
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出版当年[2011]版:
Q1 GENETICS & HEREDITY Q2 IMMUNOLOGY
最新[2023]版:
Q1 GENETICS & HEREDITY Q2 IMMUNOLOGY

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第一作者机构: [1]Harbin Med Univ, Ctr Dis Control & Prevent, Ctr Endem Dis Control, Inst Endem Fluorosis Dis, Harbin 150081, Peoples R China; [2]UTHSC, Campbell Clin, Dept Orthopaed Surg, Memphis, TN 38163 USA; [3]UTHSC, Campbell Clin, Dept BME, Memphis, TN 38163 USA;
通讯作者:
通讯机构: [1]Harbin Med Univ, Ctr Dis Control & Prevent, Ctr Endem Dis Control, Inst Endem Fluorosis Dis, Harbin 150081, Peoples R China;
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