The genome of HAdV-B14p1 strain BJ430, isolated from a six-month-old baby diagnosed with bronchial pneumonia at the Beijing Children's Hospital in December 2010, was sequenced, analyzed, and compared with reference adenovirus genome sequences archived in GenBank. This genome is 34,762 bp in length, remarkably presenting 99.9% identity with the genome from HAdV14p1 strain 303600, which was isolated in the USA (2006). Even more remarkable, it is 99.7% identical with the HAdV-B14p (prototype "de Wit'' strain) genome, isolated from The Netherlands in 1955. The patient and its parents presumably had no or limited contact with persons from the USA and Ireland, both of which reported outbreaks of the re-emergent virus HAdV-14p1 recently. These genome data, its analysis, and this report provide a reference for any additional HAdV-B14 outbreak in China and provide the basis for the development of adenovirus vaccines and molecular pathogen surveillance protocols in high-risk areas.
基金：
"China Mega-Project for Infectious Disease" from the People's Republic of China [2011ZX10004-001]
第一作者机构：[1]Chinese Ctr Dis Control & Prevent, Natl Inst Viral Dis Control & Prevent, Beijing, Peoples R China;
通讯作者：
通讯机构：[1]Chinese Ctr Dis Control & Prevent, Natl Inst Viral Dis Control & Prevent, Beijing, Peoples R China;
推荐引用方式(GB/T 7714)：
Tang Liuying,An Junjing,Xie Zhengde,et al.Genome and Bioinformatic Analysis of a HAdV-B14p1 Virus Isolated from a Baby with Pneumonia in Beijing, China[J].PLOS ONE.2013,8(3):-.doi:10.1371/journal.pone.0060345.
APA：
Tang, Liuying,An, Junjing,Xie, Zhengde,Dehghan, Shoaleh,Seto, Donald...&Ji, Yixin.(2013).Genome and Bioinformatic Analysis of a HAdV-B14p1 Virus Isolated from a Baby with Pneumonia in Beijing, China.PLOS ONE,8,(3)
MLA：
Tang, Liuying,et al."Genome and Bioinformatic Analysis of a HAdV-B14p1 Virus Isolated from a Baby with Pneumonia in Beijing, China".PLOS ONE 8..3(2013):-
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