This study was designed to find whether long-term survivors (LTSs) exhibit molecular genetic differences compared with short-term survivors (STSs) in patients with GBM. Tumors from 12 patients initially diagnosed with GBM and survived longer than 36 months (LTSs) were compared with 30 patients with GBM and STSs (survival < 18 months) for detecting of MGMT promoter methylation, 1p/19q LOH and IDH1 mutation. IDH1 mutation and MGMT promoter methylation were significantly more frequent in the LTSs group (P = 0.039 and 0.017, respectively). The incidence of 1p/19q co-deletion was not significantly different (P = 1.0). IDH1 mutation and MGMT promoter methylation might be independent, significant, and favorable factors for LTSs with GBM.
基金：
Beijing Natural Science FoundationBeijing Natural Science Foundation [7122061]
第一作者机构：[1]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China;
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China;[4]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Tiantan Xili 6, Beijing 100050, Peoples R China
推荐引用方式(GB/T 7714)：
Zhang Guo-Bin,Cui Xiang-Li,Sui Da-Li,et al.Differential molecular genetic analysis in glioblastoma multiforme of long- and short-term survivors: a clinical study in Chinese patients[J].JOURNAL OF NEURO-ONCOLOGY.2013,113(2):251-258.doi:10.1007/s11060-013-1102-x.
APA：
Zhang, Guo-Bin,Cui, Xiang-Li,Sui, Da-Li,Ren, Xiao-Hui,Zhang, Zhe...&Lin, Song.(2013).Differential molecular genetic analysis in glioblastoma multiforme of long- and short-term survivors: a clinical study in Chinese patients.JOURNAL OF NEURO-ONCOLOGY,113,(2)
MLA：
Zhang, Guo-Bin,et al."Differential molecular genetic analysis in glioblastoma multiforme of long- and short-term survivors: a clinical study in Chinese patients".JOURNAL OF NEURO-ONCOLOGY 113..2(2013):251-258
