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Rituximab regulates the expression of the Raf kinase inhibitor protein via NF-kappa B in renal tissue of rats with diabetic nephropathy

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收录情况： ◇ SCIE

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机构： [1]Guiyang Med Coll, Dept Nephrol, Affiliated Hosp, Guiyang, Guizhou Provinc, Peoples R China; [2]Capital Med Univ, Dept Nephrol, Beijing Tiantan Hosp, Beijing, Peoples R China; [3]Guiyang Med Coll, Dept Biotechnol, Guiyang, Guizhou Provinc, Peoples R China

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关键词： Diabetic nephropathy Rituximab RKIP NF-kappa B

摘要：

This study aimed to investigate the expression levels of the Raf kinase inhibitor protein (RKIP) and NF-kappa B in renal tissues of diabetic nephropathy (DN) rats, and to determine the underlying molecular targets of rituximab (RTX), with the goal of developing new clinical treatment selection for DN. Sprague-Dawley rats were randomly divided into a normal group (N), a DN group (M), and an RTX treatment group (D). Blood glucose and 24-h urine protein levels of rats were determined. The expression levels of RKIP and NF-kappa B in glomerular tissues were determined by immunohistochemistry staining and Western blotting. Comparisons between the M and N groups revealed that the concentrations of blood glucose and 24-h urine protein were significantly increased by DN (P < 0.01), and the expression levels of RKIP and NF-kappa B were significantly decreased and increased (P < 0.05), respectively. In the D group, the expression levels of RKIP and NF-kappa B were, respectively, upregulated and downregulated by RTX, and the concentrations of 24-h urine protein were also decreased by RTX. These results suggest that expression levels of RKIP might be regulated by RTX via NF-kappa B. This pathway could play an important role in the development and pathogenesis of DN. Therefore, RTX could be selected for clinical treatment of DN.

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出版当年[2012]版：

大类 | 4 区生物

小类 | 4 区生化与分子生物学 4 区遗传学

最新[2023]版：

无

JCR分区：

出版当年[2011]版：

Q4 GENETICS & HEREDITY Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

最新[2023]版：

Q4 GENETICS & HEREDITY

影响因子： 0.6 最新[2023版] 0.7 最新五年平均 1.184 出版当年[2011版] 1.161 出版当年五年平均 1.013 出版前一年[2010版] 0.994 出版后一年[2012版]

第一作者：

第一作者机构： [1]Guiyang Med Coll, Dept Nephrol, Affiliated Hosp, Guiyang, Guizhou Provinc, Peoples R China;

通讯作者：

通讯机构： [3]Guiyang Med Coll, Dept Biotechnol, Guiyang, Guizhou Provinc, Peoples R China

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