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Genome-wide DNA methylation profiling identifies ALDH1A3 promoter methylation as a prognostic predictor in G-CIMP- primary glioblastoma

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收录情况： ◇ SCIE

作者：
Zhang, Wei[1] * ; Yan, Wei[1] ; You, Gan[1] ; Bao, Zhaoshi[1] ; Wang, Yongzhi[1] ; Liu, Yanwei[1] ; You, Yongping[2] ; Jiang, Tao[1] ;
机构： [1]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China; [2]Nanjing Med Univ, Affiliated Hosp 1, Dept Neurosurg, Nanjing, Jiangsu, Peoples R China; [3]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, 6 Tiantan Xili, Beijing 100050, Peoples R China
出处：
DOI： 10.1016/j.canlet.2012.08.033
ISSN：

关键词： G-CIMP Primary glioblastoma DNA methylation IDH1 mutation Prognosis

摘要：
To date, the aberrations in the DNA methylation patterns that are associated with different prognoses of G-CIMP- primary GBMs remain to be elucidated. Here, DNA methylation profiling of primary GBM tissues from 13 long-term survivors (LTS: overall survival >= 18 months) and 20 short-term survivors (STS; overall survival <= 9 months) was performed. Then G-CIMP+ samples were excluded. The differentially expressed CpG loci were identified between residual 18 STS and 9 LTS G-CIMP- samples. Methylation levels of 11 CpG loci (10 genes) were statistically significantly lower, and 43 CpG loci (40 genes) were statistically significantly higher in the tumor tissues of LTS than those of STS G-CIMP- samples (P < 0.01). Of the 43 CpG loci that were hypermethylated in LTS G-CIMP- samples, 3 CpG loci localized in the promoter of ALDH1A3. Furthermore, using an independent validation cohort containing 37 primary GBM samples without IDH1 mutation and MGMT promoter methylation, the hypermethylation status of ALDH1A3 promoter predicted a better prognosis with an accompanied low expression of ALDH1A3 protein. Taken together, our results defined prognosis-related methylation signatures systematically for the first time in G-CIMP- primary GBMs. ALDH1A3 promoter methylation conferred a favorable prognosis in G-CIMP- primary GBMs. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81201993, 81101901]; National High Technology Research and Development Program of China (863)National High Technology Research and Development Program of China [2012AA02A508]; International Cooperation Program [2012DFA30470]; Jiangsu Province's Key Provincial Talents Program [RC2011051]; Jiangsu Province's Key Discipline of Medicine [XK201117]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2012]版：
大类 | 2 区 医学
小类 | 3 区 肿瘤学
最新[2023]版：
大类 | 1 区 医学
小类 | 2 区 肿瘤学
JCR分区：
出版当年[2011]版：
Q1 ONCOLOGY
最新[2023]版：
Q1 ONCOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2011版] 出版当年五年平均 出版前一年[2010版] 出版后一年[2012版]

第一作者：
第一作者机构： [1]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China;
通讯作者：
通讯机构： [1]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China; [3]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, 6 Tiantan Xili, Beijing 100050, Peoples R China
推荐引用方式(GB/T 7714)：
Zhang Wei,Yan Wei,You Gan,et al.Genome-wide DNA methylation profiling identifies ALDH1A3 promoter methylation as a prognostic predictor in G-CIMP- primary glioblastoma[J].CANCER LETTERS.2013,328(1):120-125.doi:10.1016/j.canlet.2012.08.033.
APA：
Zhang, Wei,Yan, Wei,You, Gan,Bao, Zhaoshi,Wang, Yongzhi...&Jiang, Tao.(2013).Genome-wide DNA methylation profiling identifies ALDH1A3 promoter methylation as a prognostic predictor in G-CIMP- primary glioblastoma.CANCER LETTERS,328,(1)
MLA：
Zhang, Wei,et al."Genome-wide DNA methylation profiling identifies ALDH1A3 promoter methylation as a prognostic predictor in G-CIMP- primary glioblastoma".CANCER LETTERS 328..1(2013):120-125

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