OBJECTIVE: The early diagnosis of nonfunctioning pituitary adenoma (NFPA) is difficult. The objective of this study was to find specific protein biomarkers to aid in the early detection of NFPA. METHODS: Serum samples from 34 patients with NFPA and 34 age- and sex-matched healthy control subjects were analysed using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) technology. The spectra were generated, protein peak clustering was performed and classification analyses were carried out using a decision tree classification algorithm. RESULTS: Nine differentially expressed serum proteins were identified in the patients with NFPA compared with the control subjects. Both the sensitivity and specificity of the decision tree classification algorithm were 82.4% for NFPA. CONCLUSIONS: Nine new serum protein biomarkers for NFPA were identified. SELDI-TOF-MS coupled with data mining tools might provide a novel approach for the early diagnosis of NFPA and population screening for the disease.
基金：
National Grant for Basic Research Program of China [2010CB912203, 2011CB915504]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [31171371, 81071055]; Medical Neurobiology of State Key Laboratory of China [09-08]
语种：
外文
被引次数：
WOS：
中科院(CAS)分区：
出版当年[2011]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
最新[2023]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
JCR分区：
出版当年[2010]版：
Q4PHARMACOLOGY & PHARMACYQ4MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q4MEDICINE, RESEARCH & EXPERIMENTALQ4PHARMACOLOGY & PHARMACY
第一作者机构：[1]Beijing Normal Univ, Minist Educ, Key Lab Cell Proliferat & Regulat Biol, Beijing 100875, Peoples R China;[2]Beijing Normal Univ, Med Res Inst, Beijing 100875, Peoples R China;[3]Univ Confederated, Inst Prote, Beijing, Peoples R China;[4]Peoples Liberat Army, Gen Hosp Artillery Force 2, Dept Endocrinol, Beijing, Peoples R China;
通讯作者：
通讯机构：[1]Beijing Normal Univ, Minist Educ, Key Lab Cell Proliferat & Regulat Biol, Beijing 100875, Peoples R China;[2]Beijing Normal Univ, Med Res Inst, Beijing 100875, Peoples R China;[3]Univ Confederated, Inst Prote, Beijing, Peoples R China;[7]Beijing Normal Univ, Minist Educ, Key Lab Cell Proliferat & Regulat Biol, 19 Xinjiekouwai St, Beijing 100875, Peoples R China
推荐引用方式(GB/T 7714)：
Hu X.,Zhang P.,Shang A.,et al.A Primary Proteomic Analysis of Serum from Patients with Nonfunctioning Pituitary Adenoma[J].JOURNAL OF INTERNATIONAL MEDICAL RESEARCH.2012,40(1):95-104.doi:10.1177/147323001204000110.
APA：
Hu, X.,Zhang, P.,Shang, A.,Li, Q.,Xia, Y....&He, D..(2012).A Primary Proteomic Analysis of Serum from Patients with Nonfunctioning Pituitary Adenoma.JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,40,(1)
MLA：
Hu, X.,et al."A Primary Proteomic Analysis of Serum from Patients with Nonfunctioning Pituitary Adenoma".JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 40..1(2012):95-104
