Aims We investigated whether CHADS2 or CHA2DS2-VASc scores could be used to predict 1-year prognosis in stroke recurrence, mortality, and mortality of ischemic stroke or transient ischemic attack (TIA) patients with nonvalvular atrial fibrillation (NVAF). Methods Patients were selected from a national prospective registry in China. The clinical prediction of the scores was examined using the C statistic. Univariate and multivariate logistic regressions were performed to analyze the relevant risk factors. Results Thousand two hundred and ninety-seven of 22,216 patients were enrolled in the study. For stroke recurrence rate, the C statistic value was 0.53 (odds ratio [OR] 1.15, 95% confidence interval [CI]: 1.01 to 1.32) for CHADS2 and 0.55 (OR 1.14, 95% CI: 1.05 to 1.24) for CHA2DS2-VASc; adding baseline National Institutes of Health Stroke Scale (NIHSS) score to these two scores, the value of C statistic was 0.58 (OR 1.25 95% CI: 1.14 to 1.37) and 0.58 (OR 1.19, 95% CI: 1.11 to 1.27), respectively. Conclusions Both CHADS2 and CHA2DS2-VASc scores have limitations in predicting the 1-year prognosis of stroke/TIA patients with NVAF in China. The predictive value of these two scores improved by adding the baseline NIHSS score.
基金：
Ministry of Science and TechnologyMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT); Ministry of Health of the People's Republic of China: National Science and Technology Major Project of China [2008ZX09312-008]; State Key Development Program of (for) Basic Research of ChinaNational Basic Research Program of ChinaState Key Development Program for Basic Research of China [2009CB521905]
第一作者机构：[1]Capital Med Univ, Dept Neurol, Beijing Tiantan Hosp, Beijing 100050, Peoples R China;
通讯作者：
通讯机构：[1]Capital Med Univ, Dept Neurol, Beijing Tiantan Hosp, Beijing 100050, Peoples R China;[2]Capital Med Univ, Dept Neurol, Beijing Tiantan Hosp, 6 Tiantanxili, Beijing 100050, Peoples R China
推荐引用方式(GB/T 7714)：
Li Shu-Ya,Zhao Xing-Quan,Wang Chun-Xue,et al.One-year Clinical Prediction in Chinese Ischemic Stroke Patients Using the CHADS2 and CHA2DS2-VASc Scores: The China National Stroke Registry[J].CNS NEUROSCIENCE & THERAPEUTICS.2012,18(12):988-993.doi:10.1111/cns.12021.
APA：
Li, Shu-Ya,Zhao, Xing-Quan,Wang, Chun-Xue,Liu, Li-Ping,Liu, Gai-Fen...&Wang, Yong-Jun.(2012).One-year Clinical Prediction in Chinese Ischemic Stroke Patients Using the CHADS2 and CHA2DS2-VASc Scores: The China National Stroke Registry.CNS NEUROSCIENCE & THERAPEUTICS,18,(12)
MLA：
Li, Shu-Ya,et al."One-year Clinical Prediction in Chinese Ischemic Stroke Patients Using the CHADS2 and CHA2DS2-VASc Scores: The China National Stroke Registry".CNS NEUROSCIENCE & THERAPEUTICS 18..12(2012):988-993
