Efficacy of Chuanxiong Ding Tong Herbal Formula Granule in the Treatment and Prophylactic of Migraine Patients: A Randomized, Double-Blind, Multicenter, Placebo-Controlled Trial
机构:[1]Beijing Univ Chinese Med, Dongzhimen Hosp, Dept Neurol, Beijing 100700, Peoples R China;[2]Minist Educ, Key Lab Internal Chinese Med, Beijing 100700, Peoples R China;[3]Beijing Univ Tradit Chinese Med, Beijing 100700, Peoples R China;[4]Changchun Univ Chinese Med, Affiliated Hosp, Dept Neurol, Changchun 130021, Peoples R China;[5]Capital Med Univ, Beijing Tiantan Hosp, Dept Tradit Chinese Med, Beijing 100050, Peoples R China;诊疗科室中医科首都医科大学附属天坛医院[6]Taian Hosp Tradit Chinese Med, Dept Neurol, Tai An 271000, Shandong, Peoples R China;[7]Xiamen Hosp Tradit Chinese Med, Dept Neurol, Xiamen 361001, Peoples R China;[8]Hubei Hosp Tradit Chinese Med, Dept Neurol, Wuhan 430061, Peoples R China;[9]Anhui Coll Tradit Chinese Med, Subsidiary Affiliated Hosp 1, Dept Neurol, Hefei 230031, Peoples R China;[10]China Acad Chinese Med Sci, Xiyuan Hosp, Dept Neurol, Beijing 100091, Peoples R China;[11]China Acad Chinese Med Sci, Beijing 100700, Peoples R China;[12]Beijing Univ Chinese Med, Dongzhimen Hosp, Dept Neurol, 5 Haiyun Cang, Beijing 100700, Peoples R China
Objective. To evaluate the efficacy of traditional Chinese herbal ChuanXiong Ding Tong herbal formula granule (CXDT-HFG) for migraine patients with "the Syndrome of Liver Wind and Blood Stasis." Methods. 150 migraine patients were recruited and assigned randomly in a double-blind, placebo-controlled study to receive CXDT-HFG (n = 99) plus necessary analgesics, or placebo (n = 51) plus necessary analgesics for 16 weeks (12 weeks' intervention and 4 weeks' follow up). Outcome measures included migraine days, frequency of migraine attacks, analgesics consumption for acute treatment, and the proportion of responders as well as the visual analogue scale (VAS) scores and intensity for pain. Results. Compared with the placebo group, the CXDT-HFG group showed significant reduction in migraine days and attacks frequency at week 12 and follow-up period (P < 0.05) as well as in the reduction of VAS scores at follow-up period. There was significant difference in the proportion of responders between the two groups at follow-up period (P = 0.014). However there were no significant differences between the two groups in analgesics consumption (P > 0.05). Conclusion. CXDT-HFG was more effective than placebo in decreasing days of migraine attacks, frequency, VAS scores, and relieving pain intensity for migraine patients.
基金:
China State Science and Technology Ministry [2007BAI20B053]
第一作者机构:[1]Beijing Univ Chinese Med, Dongzhimen Hosp, Dept Neurol, Beijing 100700, Peoples R China;
通讯作者:
通讯机构:[1]Beijing Univ Chinese Med, Dongzhimen Hosp, Dept Neurol, Beijing 100700, Peoples R China;[2]Minist Educ, Key Lab Internal Chinese Med, Beijing 100700, Peoples R China;[3]Beijing Univ Tradit Chinese Med, Beijing 100700, Peoples R China;[12]Beijing Univ Chinese Med, Dongzhimen Hosp, Dept Neurol, 5 Haiyun Cang, Beijing 100700, Peoples R China
推荐引用方式(GB/T 7714):
Fu Caihong,Yu Lihua,Zou Yihuai,et al.Efficacy of Chuanxiong Ding Tong Herbal Formula Granule in the Treatment and Prophylactic of Migraine Patients: A Randomized, Double-Blind, Multicenter, Placebo-Controlled Trial[J].EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.2012,2012:-.doi:10.1155/2012/967968.
APA:
Fu, Caihong,Yu, Lihua,Zou, Yihuai,Cao, Kegang,Zhao, Jianjun...&Lin, Dongdong.(2012).Efficacy of Chuanxiong Ding Tong Herbal Formula Granule in the Treatment and Prophylactic of Migraine Patients: A Randomized, Double-Blind, Multicenter, Placebo-Controlled Trial.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2012,
MLA:
Fu, Caihong,et al."Efficacy of Chuanxiong Ding Tong Herbal Formula Granule in the Treatment and Prophylactic of Migraine Patients: A Randomized, Double-Blind, Multicenter, Placebo-Controlled Trial".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2012.(2012):-