详情页 - 首都医科大学宣武医院知识库

当前位置：首页 > 详情页

DAPT protects brain against cerebral ischemia by down-regulating the expression of Notch 1 and Nuclear factor kappa B in rats

文献详情

资源类型：

收录情况： ◇ SCIE

作者：

机构： [1]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing 100050, Peoples R China; [2]Hebei Med Univ, Dept Neurol, Hosp 2, Shijiazhuang, Peoples R China; [3]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, 6 Tiantanxili, Beijing 100050, Peoples R China

出处：

DOI：

ISSN：

关键词： Cerebral ischemia DAPT Notch 1 Nuclear factor kappa B Inflammation

摘要：

Gamma-secretase inhibitor, N-[N-(3,5-difluorophenacetyl)-1-alanyl]-S-phenylglycine t-butyl ester (DAPT) suppresses the activation of Notch 1 signaling, which is recognized as the cell fate signaling and may participate in inflammatory processes together with NF-kappa B pathway that contributes to the brain damage after stroke. DAPT has important pharmacological roles in many diseases. However, little is known about the effect of DAPT on NF-kappa B during cerebral ischemia. This study investigated the time course expression of Notch 1 and the effects of DAPT on Notch 1 and NF-kappa B after MCAO. The results showed that Notch 1 signaling was up-regulated at the early stage after MCAO, DAPT down-regulated the expression of Notch 1 and NF-kappa B and protected brain from damage caused by MCAO. These results may indicate that the downregulation of Notch 1-NF-kappa B pathway after ischemia by administration of DAPT is a potential mechanism for its protection.

基金：

语种：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2011]版：

大类 | 4 区医学

小类 | 4 区临床神经病学 4 区神经科学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区临床神经病学 4 区神经科学

JCR分区：

出版当年[2010]版：

Q3 CLINICAL NEUROLOGY Q4 NEUROSCIENCES

最新[2023]版：

Q2 CLINICAL NEUROLOGY Q3 NEUROSCIENCES

影响因子： 2.7 最新[2023版] 2.7 最新五年平均 1.22 出版当年[2010版] 1.271 出版当年五年平均 1.12 出版前一年[2009版] 1.315 出版后一年[2011版]

第一作者：

第一作者机构： [1]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing 100050, Peoples R China;

通讯作者：

通讯机构： [1]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing 100050, Peoples R China; [3]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, 6 Tiantanxili, Beijing 100050, Peoples R China

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Neuroprotective effects of Chrysophanol against inflammation in middle cerebral artery occlusion mice [2]Role of nuclear factor-kappa B in volatile anaesthetic preconditioning with sevoflurane during myocardial ischaemia/reperfusion [3]Effect of Helicobacter pylori cdrA on interleukin-8 secretions and nuclear factor kappa B activation [4]Notch1-Nuclear Factor kappa B Involves in Oxidative Stress-Induced Alcoholic Steatohepatitis [5]Effects of aloe polysaccharide, a polysaccharide extracted from Aloe vera, on TNF-alpha-induced HaCaT cell proliferation and the underlying mechanism in psoriasis [6]ESE1 expression correlates with neuronal apoptosis in the hippocampus after cerebral ischemia/reperfusion injury [7]小剂量氢化可的松对脓毒症大鼠海马组织核因子κB表达的影响 [8]Ulinastatin suppresses lipopolysaccharide induced neuroinflammation through the downregulation of nuclear factor-kappa B in SD rat hippocampal astrocyte [9][Effect of clarithromycin on the expressions of cyclooxygenase-2 and nuclear factor-kappa B in nasal polyps in vitro]. [10]Recombinant osteopontin attenuates hyperoxia-induced acute lung injury through inhibiting nuclear factor kappa B and matrix metalloproteinases 2 and 9