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MicroRNAs involved in the EGFR/PTEN/AKT pathway in gliomas

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收录情况： ◇ SCIE

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机构： [1]Nanjing Med Univ, Dept Neurosurg, Affiliated Hosp 1, Nanjing 210029, Peoples R China; [2]Tianjin Med Univ, Dept Neurosurg, Gen Hosp, Tianjin 300052, Peoples R China; [3]Tianjin Neurol Inst, Lab Neurooncol, Tianjin 300052, Peoples R China; [4]Nantong Univ, Dept Neurosurg, Affiliated Hosp 4, Hosp Yancheng 1, Nantong 224006, Peoples R China; [5]Capital Med Univ, Dept Neurosurg, Tiantan Hosp, Beijing 100050, Peoples R China; [6]Nanjing Med Univ, Dept Neurosurg, Affiliated Hosp 1, 300 Guangzhou Rd, Nanjing 210029, Peoples R China

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关键词： MicroRNA Glioma EGFR PTEN AKT

摘要：

Gliomas are the most common type of malignant primary brain tumor. Despite advances in surgery, radiation therapy, and chemotherapy, the prognosis of patients with gliomas has not significantly improved. MicroRNAs (miRNAs), a class of non-coding RNAs, 21-25 nucleotides long, negatively regulate the expression of target genes by interacting with specific sites in mRNAs, and play a critical role in the development of gliomas. The EGFR/PTEN/AKT pathway is a promising target for anti-glioma therapy. Recent studies have showed that regulation of the EGFR/PTEN/AKT pathway by miRNAs plays a major role in glioma progression, indicating a novel way to investigate the tumorigenesis, diagnosis, and therapy of gliomas. Here, we focus on recent findings of miRNAs with respect to the EGFR/PTEN/AKT pathway in gliomas.

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出版当年[2011]版：

大类 | 3 区医学

小类 | 3 区临床神经病学 3 区肿瘤学

最新[2023]版：

大类 | 2 区医学

小类 | 3 区临床神经病学 3 区肿瘤学

JCR分区：

出版当年[2010]版：

Q2 ONCOLOGY Q2 CLINICAL NEUROLOGY

最新[2023]版：

Q2 CLINICAL NEUROLOGY Q2 ONCOLOGY

影响因子： 3.2 最新[2023版] 3.7 最新五年平均 2.929 出版当年[2010版] 2.724 出版当年五年平均 2.752 出版前一年[2009版] 3.214 出版后一年[2011版]

第一作者：

第一作者机构： [1]Nanjing Med Univ, Dept Neurosurg, Affiliated Hosp 1, Nanjing 210029, Peoples R China;

通讯作者：

通讯机构： [1]Nanjing Med Univ, Dept Neurosurg, Affiliated Hosp 1, Nanjing 210029, Peoples R China; [6]Nanjing Med Univ, Dept Neurosurg, Affiliated Hosp 1, 300 Guangzhou Rd, Nanjing 210029, Peoples R China

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