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Serum amyloid A: A new potential serum marker correlated with the stage of breast cancer

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机构: [1]Capital Med Univ, Beijing Tiantan Hosp, Lab Diag Ctr, Beijing 100050, Peoples R China; [2]Beijing Yuande BioMed Engn Co Ltd, Beijing 100176, Peoples R China
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关键词: serum amyloid A breast cancer staging diagnosis

摘要:
Previous studies reported that serum amyloid A (SAA) is elevated in patients with tumors, including breast cancer, compared to healthy controls. In addition, the levels of SAA increase gradually with tumor progression. In this study, we investigated the blood SAA level of breast cancer patients, and evaluated its potential as a serum biomarker for the early diagnosis of breast cancer and as a staging estimate. SAA protein was determined by enzyme-linked immunosorbent assay in serum samples from 30 healthy women, 21 women with benign diseases and 118 breast cancer patients who were subdivided into 4 groups based on their clinical characteristics. SAA levels were not statistically different in stage I breast cancer patients compared with the healthy controls and benign breast disease patients. SAA concentrations had medians of 0.63 mu g/ml in normal healthy women, 0.76 mu g/ml in patients with benign disease (p>0.05) and 0.82 mu g/ml in stage 1 breast cancer patients (p>0.05). By contrast, SAA values in stage II, III and IV patients had a significantly higher median compared to those of the healthy, benign breast diseases and stage 1 groups (p<0.05). Breast cancer patients with lymph node (LN) metastasis or distant metastasis were found to have significantly higher SAA concentrations than those without metastases. SAA is not a suitable marker for early breast cancer diagnosis, but its level is correlated with the stage of breast cancer. Thus, it may be a good candidate marker for the staging and prognosis of breast cancer.

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中科院(CAS)分区:
出版当年[2011]版:
大类 | 4 区 医学
小类 | 4 区 肿瘤学
最新[2023]版:
大类 | 4 区 医学
小类 | 4 区 肿瘤学
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出版当年[2010]版:
Q4 ONCOLOGY
最新[2023]版:
Q3 ONCOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2010版] 出版当年五年平均 出版前一年[2009版] 出版后一年[2011版]

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第一作者机构: [1]Capital Med Univ, Beijing Tiantan Hosp, Lab Diag Ctr, Beijing 100050, Peoples R China;
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通讯机构: [1]Capital Med Univ, Beijing Tiantan Hosp, Lab Diag Ctr, Beijing 100050, Peoples R China;
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