机构:[1]Capital Med Univ, Beijing Tiantan Hosp, Lab Diag Ctr, Beijing 100050, Peoples R China;首都医科大学附属天坛医院[2]Beijing Yuande BioMed Engn Co Ltd, Beijing 100176, Peoples R China
Previous studies reported that serum amyloid A (SAA) is elevated in patients with tumors, including breast cancer, compared to healthy controls. In addition, the levels of SAA increase gradually with tumor progression. In this study, we investigated the blood SAA level of breast cancer patients, and evaluated its potential as a serum biomarker for the early diagnosis of breast cancer and as a staging estimate. SAA protein was determined by enzyme-linked immunosorbent assay in serum samples from 30 healthy women, 21 women with benign diseases and 118 breast cancer patients who were subdivided into 4 groups based on their clinical characteristics. SAA levels were not statistically different in stage I breast cancer patients compared with the healthy controls and benign breast disease patients. SAA concentrations had medians of 0.63 mu g/ml in normal healthy women, 0.76 mu g/ml in patients with benign disease (p>0.05) and 0.82 mu g/ml in stage 1 breast cancer patients (p>0.05). By contrast, SAA values in stage II, III and IV patients had a significantly higher median compared to those of the healthy, benign breast diseases and stage 1 groups (p<0.05). Breast cancer patients with lymph node (LN) metastasis or distant metastasis were found to have significantly higher SAA concentrations than those without metastases. SAA is not a suitable marker for early breast cancer diagnosis, but its level is correlated with the stage of breast cancer. Thus, it may be a good candidate marker for the staging and prognosis of breast cancer.
第一作者机构:[1]Capital Med Univ, Beijing Tiantan Hosp, Lab Diag Ctr, Beijing 100050, Peoples R China;
通讯作者:
通讯机构:[1]Capital Med Univ, Beijing Tiantan Hosp, Lab Diag Ctr, Beijing 100050, Peoples R China;
推荐引用方式(GB/T 7714):
Zhang Guojun,Sun Xudong,Lv Hong,et al.Serum amyloid A: A new potential serum marker correlated with the stage of breast cancer[J].ONCOLOGY LETTERS.2012,3(4):940-944.doi:10.3892/ol.2012.584.
APA:
Zhang, Guojun,Sun, Xudong,Lv, Hong,Yang, Xaolin&Kang, Xixiong.(2012).Serum amyloid A: A new potential serum marker correlated with the stage of breast cancer.ONCOLOGY LETTERS,3,(4)
MLA:
Zhang, Guojun,et al."Serum amyloid A: A new potential serum marker correlated with the stage of breast cancer".ONCOLOGY LETTERS 3..4(2012):940-944