当前位置: 首页 > 详情页

The Amelioration of AH by Abstinence and the Attenuation of Oxidative Stress

文献详情

资源类型:

收录情况: ◇ SCIE

机构: [1]Capital Med Univ, Dept Gastroenterol, Beijing Tiantan Hosp, Beijing 100050, Peoples R China; [2]Capital Med Univ, Dept Gastroenterol, Beijing Tiantan Hosp, 6 Tiantan Xili, Beijing 100050, Peoples R China
出处:
ISSN:

关键词: Abstinence Alcoholic hepatitis Serum biomarkers Reactive oxidative stress Mechanism

摘要:
Background/Aims: Alcohol abstinence is considered the cornerstone in the management of alcoholic hepatitis (AH), but the degree of improvement and how abstinence ameliorates alcoholic liver injury remains unclear. The purpose of the study was to investigate the amelioration of AH after 3 and 6 months of alcohol abstinence, and its possible mechanism. Methodology: Thirty-six AH patients who strictly abstained from alcohol and 20 AH patients who did not abstain from alcohol, were followed-up for 6 months. The control group consisted of 15 healthy individuals with no history of alcohol abuse. The testing of serum biomarkers and abdominal CT scans were performed. Results: Alcohol abstinence ameliorated the AH by decreasing the liver enzyme and fibrotic markers, and improving the hepatic steatosis. Comparing between AH patients with and without alcohol abstinence, the ratio between hepatic and splenic CT value were 1.01 +/- 0.13 and 0.75 +/- 0.25, respectively (p<0.01). GSH and SOD levels were significantly higher, while the MDA level was significantly lower, in patients with abstinence compared to those without abstinence. Conclusions: Alcohol abstinence is useful in the clinical management of AH. The attenuation of AH was associated with the decrease of oxidative stress.

基金:
语种:
被引次数:
WOS:
中科院(CAS)分区:
出版当年[2011]版:
大类 | 4 区 医学
小类 | 4 区 胃肠肝病学 4 区 外科
最新[2023]版:
JCR分区:
出版当年[2010]版:
Q4 GASTROENTEROLOGY & HEPATOLOGY Q4 SURGERY
最新[2023]版:

影响因子: 最新[2023版] 最新五年平均 出版当年[2010版] 出版当年五年平均 出版前一年[2009版] 出版后一年[2011版]

第一作者:
第一作者机构: [1]Capital Med Univ, Dept Gastroenterol, Beijing Tiantan Hosp, Beijing 100050, Peoples R China;
通讯作者:
通讯机构: [1]Capital Med Univ, Dept Gastroenterol, Beijing Tiantan Hosp, Beijing 100050, Peoples R China; [2]Capital Med Univ, Dept Gastroenterol, Beijing Tiantan Hosp, 6 Tiantan Xili, Beijing 100050, Peoples R China
推荐引用方式(GB/T 7714):
APA:
MLA:

资源点击量:16409 今日访问量:0 总访问量:869 更新日期:2025-01-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 首都医科大学宣武医院 技术支持:重庆聚合科技有限公司 地址:北京市西城区长椿街45号宣武医院