机构：[1]Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China;[2]Peking Union Med Coll, Beijing 100050, Peoples R China;[3]Capital Med Univ, Beijing Tiantan Hosp, Clin Lab, Beijing 100050, Peoples R China首都医科大学附属天坛医院
The susceptibilities of vertilmicin and seven reference aminoglycosides to modifications by six recombinant aminoglycoside-modifying enzymes, AAC(6')-Ie, APH(2")-Ia, AAC(6')-Ie-APH(2")-Ia, ANT(2")-Ia, AAC(6')-Ib, and AAC(6')-Ib-cr, were studied by coupled spectrophotometric assays in microtiter plates. In comparison to other aminoglycosides, the susceptibility of vertilmicin was 45.8- to 250.0-fold lower for AAC(6')-Ie acetylation, 39.2- to 116.7-fold lower for AAC(6')-Ie-APH(2")-Ia acetylation, and 1.8- to 7.5-fold lower for ANT(2")-Ia adenylation (except that shown by amikacin) while relatively comparable for AAC(6')-Ib acetylation, AAC(6')-Ib-cr acetylation, APH(2")-Ia phosphorylation, and AAC(6')-Ie-APH(2")-Ia phosphorylation.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [30672502, 30701062]; Ministry of Sciences and Technology, People's Republic of ChinaMinistry of Science and Technology, China [2009ZX09303-005, 2009ZX09301-003, 2008ZX09305-001]
第一作者机构：[1]Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China;[2]Peking Union Med Coll, Beijing 100050, Peoples R China;
通讯作者：
通讯机构：[1]Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China;[2]Peking Union Med Coll, Beijing 100050, Peoples R China;
推荐引用方式(GB/T 7714)：
Yuan Min,Han Hui,Li Cong-Ran,et al.Susceptibility of Vertilmicin to Modifications by Three Types of Recombinant Aminoglycoside-Modifying Enzymes[J].ANTIMICROBIAL AGENTS AND CHEMOTHERAPY.2011,55(8):3950-3953.doi:10.1128/AAC.00300-11.
APA：
Yuan, Min,Han, Hui,Li, Cong-Ran,Yang, Xin-Yi,Li, Guo-Qing...&You, Xue-Fu.(2011).Susceptibility of Vertilmicin to Modifications by Three Types of Recombinant Aminoglycoside-Modifying Enzymes.ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,55,(8)
MLA：
Yuan, Min,et al."Susceptibility of Vertilmicin to Modifications by Three Types of Recombinant Aminoglycoside-Modifying Enzymes".ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 55..8(2011):3950-3953
医学