机构：[1]Beijing Tiantan Hosp, Dept Neurosurg, Beijing, Peoples R China;重点科室诊疗科室神经外科神经外科首都医科大学附属天坛医院[2]Yulin 2 Hosp, Dept Neurosurg, Yulin, Peoples R China;[3]Ningxia Med Univ, Dept Neurosurg, Ningxia, Peoples R China
To explore the expression of matrix metalloproteinase 9 (MMP-9), type IV collagen (Col IV) and vascular endothelial growth factor (VEGF) in adamantinomatous craniopharyngioma (ACP) and analyze the correlation between the level of these markers and adamantimous craniopharyngiomas recurrence. Expressions of MMP-9, Col IV and VEGF were tested by immunohistochemistry (IHC) in 40 cases of ACP, including 24 cases of primary group and 16 cases of recurred group. The expression level of MMP-9 and VEGF in recurred group were significantly higher than primary group (93.7% vs. 41.7%, P < 0.05, 87.5% vs. 45.8%, P < 0.05, respectively). The expression of Col IV in the recurred group was significant different from the primary group (Z = -2.619, P < 0.05). MMP-9, Col IV and VEGF may be the potential specific bio-marker related to the recurrence of ACP.
基金：
National Natural Funding; Beijing New Star of Technology Funding; Ningxia Natural Science Funding
第一作者机构：[2]Yulin 2 Hosp, Dept Neurosurg, Yulin, Peoples R China;
通讯作者：
通讯机构：[1]Beijing Tiantan Hosp, Dept Neurosurg, Beijing, Peoples R China;
推荐引用方式(GB/T 7714)：
Xia Zhiqiang,Liu Wenqing,Li Shengdong,et al.Expression of Matrix Metalloproteinase-9, Type IV Collagen and Vascular Endothelial Growth Factor in Adamantinous Craniopharyngioma[J].NEUROCHEMICAL RESEARCH.2011,36(12):2346-2351.doi:10.1007/s11064-011-0560-9.
APA：
Xia, Zhiqiang,Liu, Wenqing,Li, Shengdong,Jia, Ge,Zhang, Yuqi...&Gong, Jian.(2011).Expression of Matrix Metalloproteinase-9, Type IV Collagen and Vascular Endothelial Growth Factor in Adamantinous Craniopharyngioma.NEUROCHEMICAL RESEARCH,36,(12)
MLA：
Xia, Zhiqiang,et al."Expression of Matrix Metalloproteinase-9, Type IV Collagen and Vascular Endothelial Growth Factor in Adamantinous Craniopharyngioma".NEUROCHEMICAL RESEARCH 36..12(2011):2346-2351
