Oncogene addiction is a phenomenon that the survival of cancer cells depends on an activated oncogene or inactivation of tumor suppressor gene, and is regarded as the 'Achilles heel' of the successful molecular targeted therapies in cancer. However, the role of oncogene addiction in gliomas has not been elucidated systematically. In this review, we summarize the current experimental and clinical evidence for the concept of oncogene addiction and describe the mechanisms explaining oncogene addiction in gliomas. And the clinical implications for oncogene addiction in molecular targeted therapy are further emphasized. In addition, we discuss future direction for defining complex "oncogene addiction network" through the integrated analysis of multiple platforms in the flow of genetic information in gliomagenesis.
基金：
National Key Project of Science and Technology Supporting Programs [2007BAI05B08]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [30772238, 30730035]
第一作者机构：[1]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China;
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China;[2]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, 6 Tiantan Xili, Beijing 100050, Peoples R China
推荐引用方式(GB/T 7714)：
Yan Wei,Zhang Wei,Jiang Tao.Oncogene addiction in gliomas: Implications for molecular targeted therapy[J].JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH.2011,30(1):-.doi:10.1186/1756-9966-30-58.
APA：
Yan, Wei,Zhang, Wei&Jiang, Tao.(2011).Oncogene addiction in gliomas: Implications for molecular targeted therapy.JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH,30,(1)
MLA：
Yan, Wei,et al."Oncogene addiction in gliomas: Implications for molecular targeted therapy".JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 30..1(2011):-
医学