机构：[a]Department of Neurology, Lianyungang Second People's Hospital, Lianyungang Hospital of Bengbu Medical College, Lianyungang 222023, Jiangsu Province, China[b]Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China首都医科大学附属同仁医院[c]Department of Neurology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100730, China临床科室神经内科首都医科大学附属安贞医院[d]Lianyungang Second People's Hospital, Lianyungang Hospital of Bengbu Medical College, Lianyungang 222023, Jiangsu Province, China[e]Department of Radiology, Lianyungang Second People's Hospital, Lianyungang Hospital of Bengbu Medical College, Lianyungang 222023, Jiangsu Province, China
This study semi-quantitatively analyzed the effects of leukoaraiosis. Patients with moderate or severe lacunar infarction were found to exhibit low scores on the Montreal Cognitive Assess-ment Scale (F = 12.02, P = 0.000), and prolonged P300 Cz2.0 latency (F = 16.04, P = 0.000). Correlation analysis revealed that the occurrence of leukoaraiosis was negatively correlated with Montreal Cognitive Assessment scores (r = -0.416, P = 0.000), and positively correlated with P300 Cz2.0 latency (r = 0.538, P = 0.000). These findings indicate that leukoaraiosis ag-gravates cognitive impairment in patients with lacunar infarction, such that more severe leu-koaraiosis is associated with more severe cognitive decline.
第一作者机构：[a]Department of Neurology, Lianyungang Second People's Hospital, Lianyungang Hospital of Bengbu Medical College, Lianyungang 222023, Jiangsu Province, China
推荐引用方式(GB/T 7714)：
Sun D,Zhang X,Liu P,et al.Lacunar infarction with leukoaraiosis may aggravate cognitive dysfunction[J].Neural Regeneration Research.2011,6(31):2446-2451.doi:10.3969/j.issn.1673-5374.2011.31.009.
APA：
Sun, D,Zhang, X,Liu, P,Chen, J,Cao, J...&Jiang, J.(2011).Lacunar infarction with leukoaraiosis may aggravate cognitive dysfunction.Neural Regeneration Research,6,(31)
MLA：
Sun, D,et al."Lacunar infarction with leukoaraiosis may aggravate cognitive dysfunction".Neural Regeneration Research 6..31(2011):2446-2451
