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Impaired angiogenesis and mobilization of circulating angiogenic cells in HIF-1 alpha heterozygous-null mice after burn wounding

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收录情况： ◇ SCIE

作者：

机构： [1]Capital Med Univ, Beijing Tiantan Hosp, Sect Surg Sci, Beijing, Peoples R China; [2]Johns Hopkins Univ, Sch Med, Sect Surg Sci, Baltimore, MD USA; [3]Johns Hopkins Univ, Sch Med, Hendrix Burn Lab, Baltimore, MD USA; [4]Johns Hopkins Univ, Sch Med, Inst Cell Engn, Vasc Program, Baltimore, MD USA; [5]Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21205 USA; [6]Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA; [7]Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA; [8]Johns Hopkins Univ, Sch Med, Dept Radiat Oncol, Baltimore, MD USA; [9]Johns Hopkins Univ, Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA; [10]Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Baltimore, MD USA; [11]Johns Hopkins Bayview Med Ctr, Sect Surg Sci, Room 5C,A Bldg,4940 Eastern Ave, Baltimore, MD 21224 USA

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Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that controls vascular responses to hypoxia and ischemia. In this study, mice that were heterozygous (HET) for a null allele at the locus encoding the HIF-1 alpha subunit (HET mice) and their wild-type (WT) littermates were subjected to a thermal injury involving 10% of the body surface area. HIF-1 alpha protein levels were increased in burn wounds of WT but not of HET mice on day 2. The serum levels of stromal-derived factor 1 alpha, which binds to CXCR4, were increased on day 2 in WT but not in HET mice. Circulating angiogenic cells were also increased on day 2 in WT but not in HET mice and included CXCR4+Sca1+ cells. Laser Doppler perfusion imaging demonstrated increased blood flow in burn wounds of WT but not HET mice on day 7. Immunohistochemistry on day 7 revealed a reduced number of CD31+ vessels at the healing margin of burn wounds in HET as compared with WT mice. Vessel maturation was also impaired in wounds of HET mice as determined by the number of alpha-smooth muscle actin-positive vessels on day 21. The remaining wound area on day 14 was significantly increased in HET mice compared with WT littermates. The percentage of healed wounds on day 14 was significantly decreased in HET mice. These data delineate a signaling pathway by which HIF-1 promotes angiogenesis during burn wound healing.

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出版当年[2009]版：

大类 | 3 区医学

小类 | 2 区皮肤病学 3 区医学：研究与实验 3 区外科 4 区细胞生物学

最新[2023]版：

大类 | 3 区医学

小类 | 2 区皮肤病学 3 区细胞生物学 3 区医学：研究与实验 3 区外科

JCR分区：

出版当年[2008]版：

Q2 DERMATOLOGY Q2 SURGERY Q3 MEDICINE, RESEARCH & EXPERIMENTAL Q3 CELL BIOLOGY

最新[2023]版：

Q1 DERMATOLOGY Q1 SURGERY Q2 CELL BIOLOGY Q2 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 3.8 最新[2023版] 4 最新五年平均 2.152 出版当年[2008版] 2.556 出版当年五年平均 2.445 出版前一年[2007版] 2.781 出版后一年[2009版]

第一作者：

第一作者机构： [1]Capital Med Univ, Beijing Tiantan Hosp, Sect Surg Sci, Beijing, Peoples R China; [2]Johns Hopkins Univ, Sch Med, Sect Surg Sci, Baltimore, MD USA; [3]Johns Hopkins Univ, Sch Med, Hendrix Burn Lab, Baltimore, MD USA;

通讯作者：

通讯机构： [2]Johns Hopkins Univ, Sch Med, Sect Surg Sci, Baltimore, MD USA; [3]Johns Hopkins Univ, Sch Med, Hendrix Burn Lab, Baltimore, MD USA; [11]Johns Hopkins Bayview Med Ctr, Sect Surg Sci, Room 5C,A Bldg,4940 Eastern Ave, Baltimore, MD 21224 USA

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