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MicroRNA roles in beta-catenin pathway

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收录情况： ◇ SCIE

作者：

机构： [1]Tianjin Med Univ Gen Hosp, Dept Neurosurg, Tianjin 300052, Peoples R China; [2]Tianjin Neurol Inst, Lab Neurooncol, Tianjin 300052, Peoples R China; [3]Minist Educ, Key Lab Neurotrauma Variat & Regenerat, Tianjin 300052, Peoples R China; [4]Tianjin Municipal Govt, Tianjin 300052, Peoples R China; [5]Nanjing Med Univ, Affiliated Hosp 1, Dept Neurosurg, Nanjing 210029, Peoples R China; [6]Capital Med Univ, Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China

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摘要：

beta-catenin, a key factor in the Wnt signaling pathway, has essential functions in the regulation of cell growth and differentiation. Aberrant beta-catenin signaling has been linked to various disease pathologies, including an important role in tumorigenesis. Here, we review the regulation of the Wnt signaling pathway as it relates to beta-catenin signaling in tumorigenesis, with particular focus on the role of microRNAs. Finally, we discuss the potential of beta-catenin targeted therapeutics for cancer treatment.

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中科院(CAS)分区：

出版当年[2009]版：

大类 | 2 区医学

小类 | 3 区生化与分子生物学 3 区肿瘤学

最新[2023]版：

大类 | 1 区

医学

小类 | 1 区生化与分子生物学 1 区肿瘤学

JCR分区：

出版当年[2008]版：

Q1 ONCOLOGY Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

最新[2023]版：

Q1 ONCOLOGY Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

影响因子： 27.7 最新[2023版] 31.3 最新五年平均 5.362 出版当年[2008版] 0 出版当年五年平均 3.693 出版前一年[2007版] 4.16 出版后一年[2009版]

第一作者：

第一作者机构： [1]Tianjin Med Univ Gen Hosp, Dept Neurosurg, Tianjin 300052, Peoples R China; [2]Tianjin Neurol Inst, Lab Neurooncol, Tianjin 300052, Peoples R China; [3]Minist Educ, Key Lab Neurotrauma Variat & Regenerat, Tianjin 300052, Peoples R China; [4]Tianjin Municipal Govt, Tianjin 300052, Peoples R China;

通讯作者：

通讯机构： [1]Tianjin Med Univ Gen Hosp, Dept Neurosurg, Tianjin 300052, Peoples R China; [2]Tianjin Neurol Inst, Lab Neurooncol, Tianjin 300052, Peoples R China; [3]Minist Educ, Key Lab Neurotrauma Variat & Regenerat, Tianjin 300052, Peoples R China; [4]Tianjin Municipal Govt, Tianjin 300052, Peoples R China;

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