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Cerebral microbleeds - prevalence, distribution and risk factors in northeast population without preceding large-area stroke

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收录情况: ◇ SCIE ◇ 统计源期刊 ◇ 中华系列

机构: [1]Capital Med Univ, Dept Neuroradiol, Beijing Tiantan Hosp, Beijing 100050, Peoples R China; [2]Harbin Med Coll, Dept Radiol, Affiliated Hosp 1, Harbin 150001, Peoples R China; [3]Capital Med Univ, Dept Neuroradiol, Beijing Neurosurg Inst, Affiliated Beijing Tiantan Hosp, Beijing 100050, Peoples R China
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关键词: cerebral microbleeds magnetic resonance imaging gradient echo sequences hypertension factor analysis

摘要:
Background Cerebral microbleeds (CMBs) occur frequently inpatients suspected of cerebrovascular disease and they are the principle radiographic findings in patients with sub-clinical neurological impairment. The objective of this study was to assess the prevalence, distribution, severity and associated clinical features of CMBs in a prospective hospital patient based cohort undergoing brain MRI for suspected cerebrovascular disease, excluding cases with known intracranial hemorrhage or prior large-area stroke. Methods The study population consisted of 447 patients who were evaluated with T2(star)-gradient echo sequences to detect the CMBs lesion number, location, and their association with white matter hyperintensities and clinical parameters, including blood pressure. Results CMB lesions were presented in 95 of the 447 patients (21.3%). The distribution of CMBs was 43.95% cortical, 19.77% thalamic, 14.41% in the brainstem, 11.58% cerebellar, 6.21% periventricular white matter, 5.64% involving the basal ganglia regions, and 0.28% involving the hippocampus. There was a statistically significant association between the presence of CMBs and advancing age (adjusted OR 2.082, P<0.01), the severity of hypertension (adjusted OR 2.208, P<0.01). Also there was a statistically significant (P<0.01) correlation between the presence of CMBs and the severity of hypertension and white matter lesions. Conclusions CMBs occur frequently in patients with no prior large-area stroke who were referred for brain MRI for suspected cerebrovascular disease. The severity of CMBs correlates with the severity of hypertension and the presence of cerebral white matter changes detected by MRI. Chin Med J 2010;123(3):286-290

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出版当年[2009]版:
大类 | 4 区 医学
小类 | 4 区 医学:内科
最新[2023]版:
大类 | 3 区 医学
小类 | 3 区 医学:内科
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出版当年[2008]版:
Q3 MEDICINE, GENERAL & INTERNAL
最新[2023]版:
Q1 MEDICINE, GENERAL & INTERNAL

影响因子: 最新[2023版] 最新五年平均 出版当年[2008版] 出版当年五年平均 出版前一年[2007版] 出版后一年[2009版]

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第一作者机构: [1]Capital Med Univ, Dept Neuroradiol, Beijing Tiantan Hosp, Beijing 100050, Peoples R China;
通讯作者:
通讯机构: [1]Capital Med Univ, Dept Neuroradiol, Beijing Tiantan Hosp, Beijing 100050, Peoples R China; [3]Capital Med Univ, Dept Neuroradiol, Beijing Neurosurg Inst, Affiliated Beijing Tiantan Hosp, Beijing 100050, Peoples R China
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