机构：[1]Hematological Center, Beijing Children Hospital, Capital Medical University, Beijing 100045, China.医技科室职能科室临床流行病与循证医学中心血液中心首都医科大学附属北京儿童医院
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摘要：
RUNX1, also called AML1, is a member of RUNX transcriptional factor family, and also is the most frequent target for chromosomal translocations in leukemia. RUNX1 is a very important transcription factor, can enhance or repress the expressions of many hematopoiesis related genes. RUNX1 may receive a series of post-translational modifications, and the activity of RUNX1 can be affected by these post-translational modifications, thus RUNX1 regulates the differentiation, apoptosis and self-renewal of hematopoietic cells. This article reviews the role of RUNX1 in the pathogenesis of leukemia mainly including its target genes, transcriptional mechanism and post-translational modifications.
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中文
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第一作者机构：[1]Hematological Center, Beijing Children Hospital, Capital Medical University, Beijing 100045, China.
推荐引用方式(GB/T 7714)：
Zhang H,Zheng H.Y.[Epigenetic mechanism of RUNX1 in pathogenesis of leukemia].[J].Zhongguo shi yan xue ye xue za zhi.2010,18(2):525-30.
