Background: Autism, a heterogeneous disease, is described as a genetic psychiatry disorder. Recently, abnormalities at the synapse are supposed to be important for the etiology of autism. SHANK3 (SH3 and multiple ankyrin repeat domains protein) gene encodes a master synaptic scaffolding protein at postsynaptic density (PSD) of excitatory synapse. Rare mutations and copy number variation (CNV) evidence suggested SHANK3 as a strong candidate gene for the pathogenesis of autism. Methods: We performed an association study between SHANK3 gene polymorphisms and autism in Chinese Han population. We analyzed the association between five single nucleotide polymorphisms (SNPs) of the SHANK3 gene and autism in 305 Chinese Han trios, using the family based association test (FBAT). Linkage disequilibrium (LD) analysis showed the presence of LD between pairwise markers across the locus. We also performed mutation screening for the rare de novo mutations reported previously. Results: No significant evidence between any SNPs of SHANK3 and autism was observed. We did not detect any mutations described previously in our cohort. Conclusion: We suggest that SHANK3 might not represent a major susceptibility gene for autism in Chinese Han population.
基金:
National High Technology Research and Development Program of ChinaNational High Technology Research and Development Program of China [2006AA02Z195]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [30870897]; Beijing Municipal Natural Science FoundationBeijing Natural Science Foundation [7081005]
第一作者机构:[1]Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China;[2]Minist Hlth, Key Lab Mental Hlth, Beijing, Peoples R China;
通讯作者:
通讯机构:[1]Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China;[2]Minist Hlth, Key Lab Mental Hlth, Beijing, Peoples R China;
推荐引用方式(GB/T 7714):
Qin Jian,Jia Meixiang,Wang Lifang,et al.Association study of SHANK3 gene polymorphisms with autism in Chinese Han population[J].BMC MEDICAL GENETICS.2009,10:-.doi:10.1186/1471-2350-10-61.
APA:
Qin, Jian,Jia, Meixiang,Wang, Lifang,Lu, Tianlan,Ruan, Yan...&Zhang, Dai.(2009).Association study of SHANK3 gene polymorphisms with autism in Chinese Han population.BMC MEDICAL GENETICS,10,
MLA:
Qin, Jian,et al."Association study of SHANK3 gene polymorphisms with autism in Chinese Han population".BMC MEDICAL GENETICS 10.(2009):-