A dose-response relationship research on botulinum toxin type A local intramuscular injections of lower extremity spasticity in children with cerebral palsy
Objectives To observe the dose-response relationship of intramuscular injections of botulinum toxin A (BTX-A) in the spastic cerebral palsy. Methods One hundred fifty cases (age between 2 and 12 years) were randomly divided into three groups. The patients were injected with different dose of BTX-A. The movement function was evaluated with modified Ashworth scale (MAS) and physician's rating scale (PRS) at entry and 1 month after injection. The analyses were conducted with one-way analysis of variance and chi(2) test. Results The evaluation of MAS and PRS revealed a significant increase of movement function. No statistically significant differences of the side effects among three groups could be demonstrated. Conclusions The study suggested that the movement function was more significantly improved with relatively higher dose of BTX-A, which was safe and effective.
第一作者机构：[1]Beijing TianTan Hosp, Dept Pediat, Beijing 100050, Peoples R China;[2]Capital Univ Med Sci, Beijing 100050, Peoples R China
通讯作者：
通讯机构：[1]Beijing TianTan Hosp, Dept Pediat, Beijing 100050, Peoples R China;[2]Capital Univ Med Sci, Beijing 100050, Peoples R China
推荐引用方式(GB/T 7714)：
Wang Yajie,Gao Baoqin.A dose-response relationship research on botulinum toxin type A local intramuscular injections of lower extremity spasticity in children with cerebral palsy[J].CHILDS NERVOUS SYSTEM.2008,24(5):545-547.doi:10.1007/s00381-007-0571-7.
APA：
Wang, Yajie&Gao, Baoqin.(2008).A dose-response relationship research on botulinum toxin type A local intramuscular injections of lower extremity spasticity in children with cerebral palsy.CHILDS NERVOUS SYSTEM,24,(5)
MLA：
Wang, Yajie,et al."A dose-response relationship research on botulinum toxin type A local intramuscular injections of lower extremity spasticity in children with cerebral palsy".CHILDS NERVOUS SYSTEM 24..5(2008):545-547
