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Study on the pathogenic mechanism of Broca's and Wernicke's aphasia

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机构: [1]Capital Univ Med Sci, Beijing Tiantan Hosp, Dept Neurol, Beijing 100050, Peoples R China; [2]Capital Univ Med Sci, Beijing Neurosurg Inst, Dept Neuroimaging, Beijing 100050, Peoples R China; [3]Capital Univ Med Sci, Beijing Tiantan Hosp, Dept Neurol, 6 Tiantanxili,Chongwen Dist, Beijing 100050, Peoples R China
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关键词: Broca's area Wernicke's area Broca's aphasia Wernicke's aphasia mechanisms

摘要:
Objective: To study the mechanisms of aphasia by observing cerebral blood flow and metabolism changes in language functional areas of the brain using imaging, in order to develop a language rehabilitation plan for aphasia patients. Methods: Fifty-eight patients who suffered from Broca's or Wernicke's aphasia secondly to cerebral infarction were evaluated using the Western aphasia battery and Frenchay dysarthria assessment. CT and MRI were obtained to identify the location of lesions, and the language areas were analysed with magnetic resonance spectroscopy ( MRS) and perfusion-weighted imaging (PWI). The results were compared with those of the contralateral hemisphere. Results: Of the 58 patients, there were 23 Broca's aphasia patients, 29 Wernicke's aphasia patients and six other aphasia types. We excluded five patients accompanied by dysarthria, six patients with other aphasia types and 14 patients with much more disease lesions. Finally, we analysed the remaining 12 Broca's aphasia and 21 Wernicke's aphasia patients by MRS and PWI. MRS shows that the N-acetylaspartate, choline and creatine of the Broca's or Wernicke's area were reduced than those of the contralateral hemisphere, while PWI results show that the damaged Broca's or Wernicke's areas were in a hypoperfusion state. Conclusions: Broca's or Wernicke's area of aphasia patients exhibits hypoperfusion and hypometabolism, indicating that they might be the mechanisms of Broca's or Wernicke's aphasia.

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出版当年[2005]版:
大类 | 4 区 医学
最新[2025]版:
大类 | 4 区 医学
小类 | 4 区 临床神经病学 4 区 神经科学
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出版当年[2004]版:
Q3 CLINICAL NEUROLOGY Q4 NEUROSCIENCES
最新[2024]版:
Q4 CLINICAL NEUROLOGY Q4 NEUROSCIENCES

影响因子: 最新[2024版] 最新五年平均 出版当年[2004版] 出版当年五年平均 出版前一年[2003版] 出版后一年[2005版]

第一作者:
第一作者机构: [1]Capital Univ Med Sci, Beijing Tiantan Hosp, Dept Neurol, Beijing 100050, Peoples R China; [2]Capital Univ Med Sci, Beijing Neurosurg Inst, Dept Neuroimaging, Beijing 100050, Peoples R China; [3]Capital Univ Med Sci, Beijing Tiantan Hosp, Dept Neurol, 6 Tiantanxili,Chongwen Dist, Beijing 100050, Peoples R China
通讯作者:
通讯机构: [1]Capital Univ Med Sci, Beijing Tiantan Hosp, Dept Neurol, Beijing 100050, Peoples R China; [2]Capital Univ Med Sci, Beijing Neurosurg Inst, Dept Neuroimaging, Beijing 100050, Peoples R China; [3]Capital Univ Med Sci, Beijing Tiantan Hosp, Dept Neurol, 6 Tiantanxili,Chongwen Dist, Beijing 100050, Peoples R China
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