机构：[1]Univ Western Ontario, Lawson Hlth Res Inst, St Josephs Hlth Ctr, Dept Physiol & Pharmacol & Med, London, ON N6A 4V2, Canada;[2]Natl Ctr Children Hlth & Dev, Dept Perinatal Med & Maternal Care, Tokyo, Japan;[3]Univ Western Ontario, Lawson Hlth Res Inst, St Josephs Hlth Ctr, Dept Physiol & Pharmacol & Med, Room F325,268 Grosvenor St, London, ON N6A 4V2, Canada
The current study determined if interleukin-6 (IL-6) had a causative role in the lung dysfunction and/or surfactant alterations associated with three different lung insults. IL-6 (or saline) was instilled into rats followed by mechanical ventilation in vivo for 4 hours. Also, IL-6 (-/-) and wild-type mice were subjected to 3 insults: ex vivo injurious mechanical ventilation; cecal ligation and perforation; and hyperoxia exposure. In, all experiments, the presence or absence of IL-6 did not significantly influence gas exchange, lung compliance, or various surfactant measurements. These results suggest that IL-6 may have a limited, role in the sufactant alterations observed in acute lung injury.
第一作者机构：[1]Univ Western Ontario, Lawson Hlth Res Inst, St Josephs Hlth Ctr, Dept Physiol & Pharmacol & Med, London, ON N6A 4V2, Canada;[2]Natl Ctr Children Hlth & Dev, Dept Perinatal Med & Maternal Care, Tokyo, Japan;[3]Univ Western Ontario, Lawson Hlth Res Inst, St Josephs Hlth Ctr, Dept Physiol & Pharmacol & Med, Room F325,268 Grosvenor St, London, ON N6A 4V2, Canada
通讯作者：
通讯机构：[1]Univ Western Ontario, Lawson Hlth Res Inst, St Josephs Hlth Ctr, Dept Physiol & Pharmacol & Med, London, ON N6A 4V2, Canada;[2]Natl Ctr Children Hlth & Dev, Dept Perinatal Med & Maternal Care, Tokyo, Japan;[3]Univ Western Ontario, Lawson Hlth Res Inst, St Josephs Hlth Ctr, Dept Physiol & Pharmacol & Med, Room F325,268 Grosvenor St, London, ON N6A 4V2, Canada
推荐引用方式(GB/T 7714)：
Nakamura Tomoo,Moyer Brent Z.,Veldhuizen Ruud A. W.,et al.Interleukin-6 has no effect on surfactant or lung function in different lung insults[J].EXPERIMENTAL LUNG RESEARCH.2006,32(1-2):27-42.doi:10.1080/01902140600691456.
APA：
Nakamura, Tomoo,Moyer, Brent Z.,Veldhuizen, Ruud A. W.&Lewis, James F..(2006).Interleukin-6 has no effect on surfactant or lung function in different lung insults.EXPERIMENTAL LUNG RESEARCH,32,(1-2)
MLA：
Nakamura, Tomoo,et al."Interleukin-6 has no effect on surfactant or lung function in different lung insults".EXPERIMENTAL LUNG RESEARCH 32..1-2(2006):27-42
