A chromosomal DNA fragment of 8992 bp in size that has not been previously identified in Streptococcus agalactiae, was cloned and sequenced from strain 98-D60C. In particular, this 8992-bp fragment contained genes homologous to the sensor histidine kinase gene and the DNA-binding response-regulator gene of Streptococcus pneumoniae, and S. agalactiae bac gene. Structural and genetic features of the 8992-bp fragment were highly similar to those specific for bacterial pathogenicity islands. Analysis of epidemiologically unrelated S. agalactiae strains revealed that this fragment was present only in bac gene-positive strains. The possible origin of the 8992-bp fragment in S. agalactiae and its significance for molecular mechanisms of "bacteria-host" interactions are discussed.
基金：
This study was supported by the Ministry of Science and Technology (P.R.China), the Regional Public Foundation of Russian Medicine Support, and the Russian Foundation for Basic Research grant RFBR 06-04-48949.
第一作者机构：[1]Acad Med Sci, Inst Expt Med, St Petersburg 197376, Russia;[2]Capital Univ Med Sci, Beijing Childrens Hosp, Beijing 100045, Peoples R China
通讯作者：
通讯机构：[1]Acad Med Sci, Inst Expt Med, St Petersburg 197376, Russia;[2]Capital Univ Med Sci, Beijing Childrens Hosp, Beijing 100045, Peoples R China
推荐引用方式(GB/T 7714)：
Dmitriev A.,Yang Y. H.,Shen A. D.,et al.Adjacent location of the bac gene and two-component regulatory system genes within the putative Streptococcus agalactiae pathogenicity island[J].FOLIA MICROBIOLOGICA.2006,51(3):229-235.doi:10.1007/BF02932127.
APA：
Dmitriev, A.,Yang, Y. H.,Shen, A. D.&Totolian, A..(2006).Adjacent location of the bac gene and two-component regulatory system genes within the putative Streptococcus agalactiae pathogenicity island.FOLIA MICROBIOLOGICA,51,(3)
MLA：
Dmitriev, A.,et al."Adjacent location of the bac gene and two-component regulatory system genes within the putative Streptococcus agalactiae pathogenicity island".FOLIA MICROBIOLOGICA 51..3(2006):229-235
