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HCN2, NRTN, CAPS and GPX4 genes are not associated with simple febrile seizures in Chinese Han population

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机构： [a]Department of Pediatrics, Peking University First Hospital, No. 8 Xishiku Street, 100034 Beijing, China [b]Department of Central Laboratory, Peking University First Hospital, No. 8 Xishiku Street, 100034 Beijing, China [c]Bejing Children's Hospital, Beijing, China [d]Capital Institute of Pediatrics, Beijing, China [e]Laboratory of Molecular Biology, Hebei Cancer Institute, Hebei Medical University, Shijiazhuang, China [f]Department of Neurology, People's Hospital of Hebei Province, Shijiazhuang, China

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关键词： Chinese Febrile seizures Linkage Single nucleotide polymorphism

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Febrile seizures (FS) are considered as a genetic disease, but the specific genes responsible for it have not yet been identified. Based on our previous linkage analysis data that mapped our simple FS families to 19p13.3 and the function of the genes in this region, four genes (HCN2, NRTN, CAPS and GPX4) were chosen as candidate genes for FS. To investigate the possibility of association of these four genes with FS in Chinese Han population, we systematically screened all exons and their flanking introns of the four genes and found 22 single nucleotide polymorphisms (SNPs). Using nine of the SNPs as markers, we conducted association studies in 60 FS patients and 101 normal controls. No significant discrepancies between the FS cases and controls were found in allele and genotype frequencies of the four SNPs in HCN2 gene, one SNP in NRTN gene, one SNP in CAPS gene and three SNPs in GPX4 gene. Our results imply that the four genes are not the susceptibility genes for FS at least in Chinese population. © 2006 IOS Press. All rights reserved.

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