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Functional prognosis affected by temperature control treatment in the near future in patients with stroke

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机构: [a]Department of Neurology, Beijing Longfu Hospital, Beijing 100010, China [b]Department of Neurology, Beijing Tiantan Hospital, Capital University of Medical Sciences, Beijing 100010, China
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Aim: To observe the effect of the decrease of body temperature gently for 72 hours on the function prognosi in patients with stroke under the setting condition. Methods: Six-four patients with acute stroke in Department of Neurology of Beijing Longfu Hospital from June 2001 to June 2003. They were divided randomly into 32 cases in treatment group with 20 males and 12 femals, including 26 cerebral arterial thrombosis cases, and 6 hemorrhagic apoplexy aged cases from 43 to 74 years old; Thirty-two cases in control group with 23 mals and 9 femals, including 25 cerebral arterial thrombosis cases, and 7 hemorrhagic apoplexy cases aged from 45 to 77 years old. All the patients in the two groups were treated with routine drugs, and given reasonable sports rehabilitation according to disability situation. The muscle and pine mixture was treated on patients in treatment group to maintain sub-hibernation behavior. Using electric homeothermia hypothermic blanket anus temperature fixed at 35.5-36.0 °C for 24-72 hours; Rewarming was used by natural slowing method and rising 1 °C every 4-6 hours. When entered the group, after 1 week and after 30 days all the patients were performed respectively by MESSS, and the highest mark was 45 points and the lowest mark was 0 point. The higher the mark, the more serious the defection; The activities of daily living was evaluated by Barthel index, including 10 contents, and the highest mark was 100 points and the lowest mark that was the most severity was 0 point. Results: Totally 64 patients were involved in the result analysis. 1 The improved value of neurologic impairment: It was significantly higher in treatment group than that in control group one week after treatment [(6.35±4.92), (1.21±1.02) points, (t=2.864,P < 0.01)]. It was also significantly higher in treatment group than that in control group 30 days after treatment [(12.85±5.87), (9.84±3.94) points, (t=2.958,P < 0.01)]. 2 The score of Barthel index: It was higher in treatment group than that in control group one week after treatment [(54.28±8.38), (49.76±7.31)points, (t=2.206,P < 0.05)] It was also significantly higher in treatment group than that in control group 30 days after treatment [(86.72±7.94), (67.34 ±8.63 ) points, (t=2.812, P < 0.01)]. Conclusion: The earlier period gently hypothermia can significantly ameliorate the level of neurologic impairment, improve the ability of activities of daily living, and the prognosis in the near future is preferable.

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