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A collagen-GAG implant for dura mater tissue engineering in a canine model

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机构: [a]Orthopaedic Res. Lab., Brigham/Women's Hosp./Tissue Eng., VA Boston Healthcare System, Boston, MA, United States [b]Department of Neurology, Tian Jing Huan Hu Hospital, Tian Jing, China [c]Department of Neurology, Beijing Tian Tan Hospital, Beijing, China [d]Mechanical Engineering, Massachusetts Inst. of Technology, Cambridge, MA, United States
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A canine model for a dural defect was used to evaluate the tissue response to a collagen based matrices cross-linked and sterilized using different methods. Type-1 collagen-GAG implant with dehydrothermal (DHT) treatment was commended for treatment of dural defect by its induction of the least number and severity of adhesion. It was observed that collagen alone implant induced more adhesions. The results show that a DHT-crosslinked collagen GAG implant can be a useful alternative to an autologous tissue graft for the treatment of dural defects.

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