To discuss the clinical features, diagnosis and management of recurrent pituitary adenoma. 38 cases of recurrent pituitary adenoma presented in our hospital during a period from January 1997 to May 1999 were analyzed retrospectively, and the relative references were reviewed. All cases were confirmed by surgery and pathology. The average recurrent interval of pituitary adenoma was 5.1 years, ranging from 3 months to 18 years. The main clinical manifestations were visual interference, pituitary dysfunction and headache. CT and MRI showed masses in the sellar region with contrast enhancement. Repeated surgeries were performed in 25 cases via transfrontal approach, 13 cases via transsphenoidal. Twenty-nine of 35 cases with visual interference were resolved, no improvement was achieved in 6 cases. Ten of 13 cases with PRL above normal level recovered within one week after surgery and no death was seen. 31 cases were followed up, and showed satisfying results. The diagnosis of recurrent pituitary adenoma mainly relies on the analysis of clinical manifestations, endocrinological and neuroradiological examinations. Operative management, medical treatment and radiation therapy are all treatment of choice for recurrent pituitary adenoma; while surgery is a main and effective method.