Objective To compare the results from serology to DNA gene typing method, and by analysing the real HLA-A-C-B haplotype to evaluate their significance. Methods Two large clans with 14 small families total 83 individuals in an isolated village in Anhui province were HLA typed using both serology and DNA methods. Haplotypes were deduced according to the genetic segregation. Results The results showed that the total error appeared in serology was 17. 2% m comparison with DNA typing. This error could be partly corrected by reassignment in accordance with DNA typing. Twelve alleles were identified in HLA-A locus, 19 in B locus, and 11 in C locus. Thirty five haplotypes were found. The linkage disequilibrium in HLA-C-B loci was greater than in A-C. Three ancestor haplotypes were indentified. Conclusions The existence of genetic drift may be the major factor in contribution of the haplotype differentiation in this isolated population.
语种：
中文
第一作者：
第一作者机构：[1]Beijing Pediatric Institute, Beijing Children's Hospital, Beijing 100045, China
推荐引用方式(GB/T 7714)：
Lin L,Gao X,Zhu W.A study on HLA-A-C-B haplotype in Chinese with DNA typing[J].1999,19(2):
