To summarize the operation experience of resecting petroclival region tumors by lateral approaches. (1) Ameliorate pterion approach; (2) temporal-occipital transtentorial-transpetrous approach; (3) transpetrous combined with supratentorial and infratentorial presigmoid approach; (4) far lateral transcondylar approach were applied for 61 patients with petroclival region tumor. Of the 61 tumors studied, 54 were completely resected, 6 were nearly complete and 1 was subtotally resected. No patient died in this group, 37 patients were followed up, and all showed satisfying results. 45% of the patients had CNs deficit, with III, VI, V, VIII, IX, X, XII nerve deficits most commonly seen. Lateral approaches are recommended for total resection of petroclival region tumors. HoVDever the operative techniques are complex and potential risks of morbidity exist.