机构：[1]UNIV TEXAS,SW MED CTR,DALLAS,TX 75230;[2]CHINA JAPAN FRIENDSHIP HOSP,BEIJING,PEOPLES R CHINA;[3]BEIJING CHILDRENS HOSP,BEIJING,PEOPLES R CHINA首都医科大学附属北京儿童医院
We have determined alleles of HLA-DRB1, DRB3, DRB5, DQA1, DQB1, and DPB1 loci in 91 unrelated healthy individuals from North China. Group-specific PCR primers were employed for the analysis of subsets of DR1. DR2, DR4, DRw52, and DPB. With allele-specific probes, 22 DRB1, 8 DQA1, 13 DQB1, and 12 DPB1 alleles were found in this panel. Allele frequencies showed that 25.3% of the subjects had DR7 and 26.4% had DR9, only 5.5% had DRB1*0301 (DRw17). In the DR4 group, DRB1*0405 (Dw15, 8.8%) and 0406 (KT2, 9.9%) were the most prevalent alleles. DRB1*0404 (Dw14.1), 0407 (Dwl3.2) and 0408 (Dw14.2) were absent and the other alleles of the DR4 group were rare. The most common DRw6 subset was DRB1*1401 (8.8%). DRB1*0802 and 0803 were present (2.2%, 6.6%), and DRB1*0801 was not found. Associations with DQA1 and DQB1 were generally similar to those found in other populations. DPB1*0501 was the most frequent (60.2%) allele at the DPB1 locus. Overall our study shows that the distribution of class II alleles in a population from Mainland China is quite different from other ethnic groups. The high frequency of the KT2 subset of DR4 (DRB1*0406) and of DPB1*0501 are the most striking features found. A new type of DR4 was determined in one subject. It was like DR4-Dw15 (DRB1*0405) but, according to our hybridization patterns, it encoded valine instead of glycine in position 86. It is now called DRB1*0410.
基金：
NIAID NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Allergy & Infectious Diseases (NIAID) [R01-AI21278, P01-AI23271]; NIAMS NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) [P50-AR39169]
语种：
外文
被引次数：
WOS：
第一作者：
第一作者机构：[1]UNIV TEXAS,SW MED CTR,DALLAS,TX 75230;[2]CHINA JAPAN FRIENDSHIP HOSP,BEIJING,PEOPLES R CHINA;[3]BEIJING CHILDRENS HOSP,BEIJING,PEOPLES R CHINA
推荐引用方式(GB/T 7714)：
GAO XJ,SUN YP,AN JB,et al.DNA TYPING FOR HLA-DR, HLA-DQ AND HLA-DP ALLELES IN A CHINESE POPULATION USING THE POLYMERASE CHAIN-REACTION (PCR) AND OLIGONUCLEOTIDE PROBES[J].TISSUE ANTIGENS.1991,38(1):24-30.doi:10.1111/j.1399-0039.1991.tb02031.x.
APA：
GAO, XJ,SUN, YP,AN, JB,FERNANDEZVINA, M,QOU, JN...&STASTNY, P.(1991).DNA TYPING FOR HLA-DR, HLA-DQ AND HLA-DP ALLELES IN A CHINESE POPULATION USING THE POLYMERASE CHAIN-REACTION (PCR) AND OLIGONUCLEOTIDE PROBES.TISSUE ANTIGENS,38,(1)
MLA：
GAO, XJ,et al."DNA TYPING FOR HLA-DR, HLA-DQ AND HLA-DP ALLELES IN A CHINESE POPULATION USING THE POLYMERASE CHAIN-REACTION (PCR) AND OLIGONUCLEOTIDE PROBES".TISSUE ANTIGENS 38..1(1991):24-30
