机构：[1]BEIJING NEUROSURG INST,BEIJING 100050,PEOPLES R CHINA研究所北京市神经外科研究所首都医科大学附属天坛医院[2]CHINESE ACAD MED SCI,INST MAT MED,BEIJING 100050,PEOPLES R CHINA
The effects of verticillatine (Ver), hexamethonium (Hex) and nimodipine (Nim) on mean arterial pressure (MAP), cerebral blood flow (CBF) and cerebrovascular resistance (CVR) were determined in pentobarbital anesthetized animals using the method of electromagnetic flow meter in dogs and hydrogen clearance in cats. Ver or Nim iv induced significant reduction of MAP and CVR. CBF was increased in dogs and unaltered in cats. The Hex treated dogs and cata exhibited a fall of MAP and CBF with enhancement of CVR. In cats after middle cerebral artery occlusion (MCAO), regional cerebral blood flow (rCBF) was reduced from 190 +/- 70 to 90 +/- 20 ml . kg-1 . min-1. Ver and Nim iv caused similar changes of MAP and CVR to those before MCAO. The results suggest that Ver and Nim may have vasodilation effect and improve the cerebral circulation. Thus, they would be beneficial to patients suffering from hypertension.
第一作者机构：[1]BEIJING NEUROSURG INST,BEIJING 100050,PEOPLES R CHINA[2]CHINESE ACAD MED SCI,INST MAT MED,BEIJING 100050,PEOPLES R CHINA
通讯作者：
通讯机构：[1]BEIJING NEUROSURG INST,BEIJING 100050,PEOPLES R CHINA[2]CHINESE ACAD MED SCI,INST MAT MED,BEIJING 100050,PEOPLES R CHINA
推荐引用方式(GB/T 7714)：
ZENG GY,TIAN BH,ZHOU R,等.EFFECTS OF VERTICILLATINE ON CEREBRAL BLOOD-FLOW, CEREBRAL VASCULAR-RESISTANCE AND BLOOD-PRESSURE IN ANESTHETIZED DOGS AND CATS[J].ACTA PHARMACOLOGICA SINICA.1991,12(5):471-474.
医学